Structural advances on titin : towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding

Zacharchenko, Thomas; Castelmur, Eleonore von; Rigden, Daniel J.; Mayans, Olga

Structural advances on titin : towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding

Files

Zacharchenko_0-309418.pdf(1.07 MB)

Date

2015

Authors

Zacharchenko, Thomas

Castelmur, Eleonore von

Rigden, Daniel J.

Mayans, Olga

Publication type

Journal article

Publication status

Published

Published in

Biochemical Society Transactions ; 43 (2015), 5. - pp. 850-855. - ISSN 0300-5127. - eISSN 1470-8752

Abstract

Titin is a gigantic filamentous protein of the muscle sarcomere that plays roles in myofibril mechanics and homoeostasis. 3D-structures of multi-domain fragments of titin are now available that start revealing the molecular mechanisms governing its mechanical and scaffolding functions. This knowledge is now being translated into the fabrication of self-assembling biopolymers. Here we review the structural advances on titin, the novel concepts derived from these and the emerging translational avenues.

Subject (DDC)

570 Biosciences, Biology

Cite This

ISO 690

ZACHARCHENKO, Thomas, Eleonore von CASTELMUR, Daniel J. RIGDEN, Olga MAYANS, 2015. Structural advances on titin : towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding. In: Biochemical Society Transactions. 43(5), pp. 850-855. ISSN 0300-5127. eISSN 1470-8752. Available under: doi: 10.1042/BST20150084

BibTex

@article{Zacharchenko2015-10-01Struc-32253,
  year={2015},
  doi={10.1042/BST20150084},
  title={Structural advances on titin : towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding},
  number={5},
  volume={43},
  issn={0300-5127},
  journal={Biochemical Society Transactions},
  pages={850--855},
  author={Zacharchenko, Thomas and Castelmur, Eleonore von and Rigden, Daniel J. and Mayans, Olga}
}

RDF

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/32253">
    <dc:contributor>Castelmur, Eleonore von</dc:contributor>
    <dc:contributor>Mayans, Olga</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-11-25T16:02:35Z</dc:date>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Mayans, Olga</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/32253/4/Zacharchenko_0-309418.pdf"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-11-25T16:02:35Z</dcterms:available>
    <dcterms:abstract xml:lang="eng">Titin is a gigantic filamentous protein of the muscle sarcomere that plays roles in myofibril mechanics and homoeostasis. 3D-structures of multi-domain fragments of titin are now available that start revealing the molecular mechanisms governing its mechanical and scaffolding functions. This knowledge is now being translated into the fabrication of self-assembling biopolymers. Here we review the structural advances on titin, the novel concepts derived from these and the emerging translational avenues.</dcterms:abstract>
    <dc:contributor>Rigden, Daniel J.</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:title>Structural advances on titin : towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding</dcterms:title>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/32253/4/Zacharchenko_0-309418.pdf"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/32253"/>
    <dc:creator>Castelmur, Eleonore von</dc:creator>
    <dc:creator>Zacharchenko, Thomas</dc:creator>
    <dc:creator>Rigden, Daniel J.</dc:creator>
    <dc:contributor>Zacharchenko, Thomas</dc:contributor>
    <dcterms:issued>2015-10-01</dcterms:issued>
    <dc:language>eng</dc:language>
  </rdf:Description>
</rdf:RDF>

Bibliography of Konstanz

Yes