The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity

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2011
Autor:innen
Kappes, Ferdinand
Mathew, Veena
Yu, Jindan
Zhang, Ling
Khodadoust, Michael S.
Chinnaiyan, Arul M.
Luger, Karolin
Schneider, Robert
Markovitz, David M.
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Genes & Development. 2011, 25(7), pp. 673-678. ISSN 0890-9369. eISSN 1549-5477. Available under: doi: 10.1101/gad.2036411
Zusammenfassung

Heterochromatin integrity is crucial for genome stability and regulation of gene expression, but the factors involved in mammalian heterochromatin biology are only incompletely understood. Here we identify the oncoprotein DEK, an abundant nuclear protein with a previously enigmatic in vivo function, as a Suppressor of Variegation [Su(var)] that is crucial to global heterochromatin integrity. We show that DEK interacts directly with Heterochromatin Protein 1 α (HP1α) and markedly enhances its binding to trimethylated H3K9 (H3K9me3), which is key for maintaining heterochromatic regions. Loss of Dek in Drosophila leads to a Su(var) phenotype and global reduction in heterochromatin. Thus, these findings show that DEK is a key factor in maintaining the balance between heterochromatin and euchromatin in vivo.

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570 Biowissenschaften, Biologie
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heterochromatin, oncogene, HP1-α, epigenetics, Su(var)
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ISO 690KAPPES, Ferdinand, Tanja WALDMANN, Veena MATHEW, Jindan YU, Ling ZHANG, Michael S. KHODADOUST, Arul M. CHINNAIYAN, Karolin LUGER, Robert SCHNEIDER, David M. MARKOVITZ, 2011. The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity. In: Genes & Development. 2011, 25(7), pp. 673-678. ISSN 0890-9369. eISSN 1549-5477. Available under: doi: 10.1101/gad.2036411
BibTex
@article{Kappes2011-04-01oncop-38816,
  year={2011},
  doi={10.1101/gad.2036411},
  title={The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity},
  number={7},
  volume={25},
  issn={0890-9369},
  journal={Genes & Development},
  pages={673--678},
  author={Kappes, Ferdinand and Waldmann, Tanja and Mathew, Veena and Yu, Jindan and Zhang, Ling and Khodadoust, Michael S. and Chinnaiyan, Arul M. and Luger, Karolin and Schneider, Robert and Markovitz, David M.}
}
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