Development of Non-Erythropoietic Erythropoietin Variants for Neuroprotection

Torup, Lars; Leist, Marcel

Development of Non-Erythropoietic Erythropoietin Variants for Neuroprotection

Files

Hoke_Chapter_13_final.pdf(173.05 KB)

Date

2006

Authors

Torup, Lars

Leist, Marcel

Publication type

Contribution to a collection

Published in

Erythropoietin and the Nervous System / Höke, Ahmet (ed.). - Berlin : Springer, 2006. - pp. 1-9

Abstract

Erythropoietin is well known to possess erythropoietic activity, but also tissue protection. Here, we present examples on how to separate these two activities. One possibility is to generate a short-lived variant by removal of EPO s sialic acid residues. Although asialo-EPO has a high affinity for the classical EPO-R, it lacks hematopoetic activity in vivo upon bolus injection, because of its short plasma half-life. Another approach we followed was to generate carbamylated EPO (CEPO), which has no affinity for the EPO receptor, but the same neuroprotective potency as EPO. Our data suggest that the cytoprotective signal transduction of EPO is distinct from the hematopoietic signaling machinery.

Subject (DDC)

570 Biosciences, Biology

Keywords

Asialo-EPO,carbamylation,chemical modification,mutation,neuroprotection

Cite This

ISO 690

TORUP, Lars, Marcel LEIST, 2006. Development of Non-Erythropoietic Erythropoietin Variants for Neuroprotection. In: HÖKE, Ahmet, ed.. Erythropoietin and the Nervous System. Berlin:Springer, pp. 1-9

BibTex

@incollection{Torup2006Devel-7441,
  year={2006},
  title={Development of Non-Erythropoietic Erythropoietin Variants for Neuroprotection},
  publisher={Springer},
  address={Berlin},
  booktitle={Erythropoietin and the Nervous System},
  pages={1--9},
  editor={Höke, Ahmet},
  author={Torup, Lars and Leist, Marcel}
}

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Bibliography of Konstanz

Yes