Publikation: Development of Non-Erythropoietic Erythropoietin Variants for Neuroprotection
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2006
Autor:innen
Torup, Lars
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Published
Erschienen in
HÖKE, Ahmet, ed.. Erythropoietin and the Nervous System. Berlin: Springer, 2006, pp. 1-9
Zusammenfassung
Erythropoietin is well known to possess erythropoietic activity, but also tissue protection. Here, we present examples on how to separate these two activities. One possibility is to generate a short-lived variant by removal of EPO s sialic acid residues. Although asialo-EPO has a high affinity for the classical EPO-R, it lacks hematopoetic activity in vivo upon bolus injection, because of its short plasma half-life. Another approach we followed was to generate carbamylated EPO (CEPO), which has no affinity for the EPO receptor, but the same neuroprotective potency as EPO. Our data suggest that the cytoprotective signal transduction of EPO is distinct from the hematopoietic signaling machinery.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Asialo-EPO, carbamylation, chemical modification, mutation, neuroprotection
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TORUP, Lars, Marcel LEIST, 2006. Development of Non-Erythropoietic Erythropoietin Variants for Neuroprotection. In: HÖKE, Ahmet, ed.. Erythropoietin and the Nervous System. Berlin: Springer, 2006, pp. 1-9BibTex
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address={Berlin},
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<dcterms:abstract xml:lang="eng">Erythropoietin is well known to possess erythropoietic activity, but also tissue protection. Here, we present examples on how to separate these two activities. One possibility is to generate a short-lived variant by removal of EPO s sialic acid residues. Although asialo-EPO has a high affinity for the classical EPO-R, it lacks hematopoetic activity in vivo upon bolus injection, because of its short plasma half-life. Another approach we followed was to generate carbamylated EPO (CEPO), which has no affinity for the EPO receptor, but the same neuroprotective potency as EPO. Our data suggest that the cytoprotective signal transduction of EPO is distinct from the hematopoietic signaling machinery.</dcterms:abstract>
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