Investigation of Microcystin Congener-Dependent Uptake into Primary Murine Neurons
Investigation of Microcystin Congener-Dependent Uptake into Primary Murine Neurons
Loading...
Date
2010
Editors
Journal ISSN
Electronic ISSN
ISBN
Bibliographical data
Publisher
Series
URI (citable link)
DOI (citable link)
International patent number
Link to the license
EU project number
Project
Open Access publication
Collections
Title in another language
Publication type
Journal article
Publication status
Published in
Environmental Health Perspectives ; 118 (2010), 10. - pp. 1370-1375. - eISSN 0091-6765
Abstract
Contamination of natural waters by toxic cyanobacteria is a growing problem worldwide, resulting in serious water pollution and human health hazards. Microcystins (MCs) represent a group of > 80 cyclic heptapeptides, mediating cytotoxicity via specific protein phosphatase (PP) inhibition at equimolar concentrations (comparable toxicodynamics). Because of the structure and size of MCs, active uptake into cells occurs via organic anion-transporting polypeptides (OATP/Oatp), as confirmed for liver-specific human OATP1B1 and OATP1B3, mouse Oatp1b2 (mOatp1b2), skate Oatp1d1, and the more widely distributed OATP1A2 expressed, for example, at the blood-brain barrier. Tissue-specific and cell-type-specific expression of OATP/Oatp transporters and specific transport of MC congeners (toxicokinetics) therefore appear prerequisite for the reported toxic effects in humans and other species upon MC exposure. Beyond hepatotoxicity induced by the MC-LR congener, the effects of other MC congeners, especially neuronal uptake and toxicity, are unknown.
Summary in another language
Subject (DDC)
570 Biosciences, Biology
Keywords
cyanobacteria,microcystin congeners,neurotoxicity,organic anion-transporting polypeptides
Conference
Review
undefined / . - undefined, undefined. - (undefined; undefined)
Cite This
ISO 690
FEURSTEIN, Daniel, Julia KLEINTEICH, Alexandra H. HEUSSNER, Kerstin STEMMER, Daniel R. DIETRICH, 2010. Investigation of Microcystin Congener-Dependent Uptake into Primary Murine Neurons. In: Environmental Health Perspectives. 118(10), pp. 1370-1375. eISSN 0091-6765. Available under: doi: 10.1289/ehp.0901289BibTex
@article{Feurstein2010Inves-7712, year={2010}, doi={10.1289/ehp.0901289}, title={Investigation of Microcystin Congener-Dependent Uptake into Primary Murine Neurons}, number={10}, volume={118}, journal={Environmental Health Perspectives}, pages={1370--1375}, author={Feurstein, Daniel and Kleinteich, Julia and Heussner, Alexandra H. and Stemmer, Kerstin and Dietrich, Daniel R.} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/7712"> <dc:contributor>Heussner, Alexandra H.</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Stemmer, Kerstin</dc:contributor> <dcterms:abstract>Contamination of natural waters by toxic cyanobacteria is a growing problem worldwide, resulting in serious water pollution and human health hazards. Microcystins (MCs) represent a group of > 80 cyclic heptapeptides, mediating cytotoxicity via specific protein phosphatase (PP) inhibition at equimolar concentrations (comparable toxicodynamics). Because of the structure and size of MCs, active uptake into cells occurs via organic anion-transporting polypeptides (OATP/Oatp), as confirmed for liver-specific human OATP1B1 and OATP1B3, mouse Oatp1b2 (mOatp1b2), skate Oatp1d1, and the more widely distributed OATP1A2 expressed, for example, at the blood-brain barrier. Tissue-specific and cell-type-specific expression of OATP/Oatp transporters and specific transport of MC congeners (toxicokinetics) therefore appear prerequisite for the reported toxic effects in humans and other species upon MC exposure. Beyond hepatotoxicity induced by the MC-LR congener, the effects of other MC congeners, especially neuronal uptake and toxicity, are unknown.</dcterms:abstract> <dc:creator>Dietrich, Daniel R.</dc:creator> <dc:creator>Feurstein, Daniel</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7712/1/Feurstein_2010.pdf"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:34Z</dc:date> <dc:creator>Kleinteich, Julia</dc:creator> <dcterms:issued>2010</dcterms:issued> <dc:contributor>Dietrich, Daniel R.</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Feurstein, Daniel</dc:contributor> <dc:contributor>Kleinteich, Julia</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7712"/> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7712/1/Feurstein_2010.pdf"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:34Z</dcterms:available> <dc:creator>Heussner, Alexandra H.</dc:creator> <dcterms:title>Investigation of Microcystin Congener-Dependent Uptake into Primary Murine Neurons</dcterms:title> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dcterms:bibliographicCitation>First publ. in: Environmental Health Perspectives 118 (2010), 10, pp. 1370-1375</dcterms:bibliographicCitation> <dc:creator>Stemmer, Kerstin</dc:creator> <dc:format>application/pdf</dc:format> <dc:rights>terms-of-use</dc:rights> </rdf:Description> </rdf:RDF>
Internal note
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Examination date of dissertation
Method of financing
Comment on publication
Alliance license
Corresponding Authors der Uni Konstanz vorhanden
International Co-Authors
Bibliography of Konstanz
Yes