Identification of toxic 2,4-decadienal in oxidized, low-density lipoprotein by solid-phase microextraction
Identification of toxic 2,4-decadienal in oxidized, low-density lipoprotein by solid-phase microextraction
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2000
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Spiteller, Gerhard
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Angewandte Chemie International Edition ; 39 (2000), 3. - pp. 583-585. - ISSN 1433-7851
Abstract
The oxidation of low-density lipoprotein (LDL) in vitro was studied by a combination of solid-phase microextraction and GC/MS. 2-trans,4-cis-2,4-Decadienal, which is strongly toxic in vitro, was detected as the early oxidation product. This compound is degraded further to hexanal and (by cyclization of 4-hydroxy-2-nonenal) to 2-pentylfuran.
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570 Biosciences, Biology
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aldehydes,lipids,lipoproteins,oxygenations
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SPITELLER, Dieter, Gerhard SPITELLER, 2000. Identification of toxic 2,4-decadienal in oxidized, low-density lipoprotein by solid-phase microextraction. In: Angewandte Chemie International Edition. 39(3), pp. 583-585. ISSN 1433-7851. Available under: doi: 10.1002/(SICI)1521-3773(20000204)39:3<583::AID-ANIE583>3.0.CO;2-OBibTex
@article{Spiteller2000Ident-15586, year={2000}, doi={10.1002/(SICI)1521-3773(20000204)39:3<583::AID-ANIE583>3.0.CO;2-O}, title={Identification of toxic 2,4-decadienal in oxidized, low-density lipoprotein by solid-phase microextraction}, number={3}, volume={39}, issn={1433-7851}, journal={Angewandte Chemie International Edition}, pages={583--585}, author={Spiteller, Dieter and Spiteller, Gerhard} }
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