Identification of toxic 2,4-decadienal in oxidized, low-density lipoprotein by solid-phase microextraction

Spiteller, Dieter; Spiteller, Gerhard

Identification of toxic 2,4-decadienal in oxidized, low-density lipoprotein by solid-phase microextraction

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Date

2000

Authors

Spiteller, Dieter

Spiteller, Gerhard

Publication type

Journal article

Published in

Angewandte Chemie International Edition ; 39 (2000), 3. - pp. 583-585. - ISSN 1433-7851

Abstract

The oxidation of low-density lipoprotein (LDL) in vitro was studied by a combination of solid-phase microextraction and GC/MS. 2-trans,4-cis-2,4-Decadienal, which is strongly toxic in vitro, was detected as the early oxidation product. This compound is degraded further to hexanal and (by cyclization of 4-hydroxy-2-nonenal) to 2-pentylfuran.

Subject (DDC)

570 Biosciences, Biology

Keywords

aldehydes,lipids,lipoproteins,oxygenations

Cite This

ISO 690

SPITELLER, Dieter, Gerhard SPITELLER, 2000. Identification of toxic 2,4-decadienal in oxidized, low-density lipoprotein by solid-phase microextraction. In: Angewandte Chemie International Edition. 39(3), pp. 583-585. ISSN 1433-7851. Available under: doi: 10.1002/(SICI)1521-3773(20000204)39:3<583::AID-ANIE583>3.0.CO;2-O

BibTex

@article{Spiteller2000Ident-15586,
  year={2000},
  doi={10.1002/(SICI)1521-3773(20000204)39:3<583::AID-ANIE583>3.0.CO;2-O},
  title={Identification of toxic 2,4-decadienal in oxidized, low-density lipoprotein by solid-phase microextraction},
  number={3},
  volume={39},
  issn={1433-7851},
  journal={Angewandte Chemie International Edition},
  pages={583--585},
  author={Spiteller, Dieter and Spiteller, Gerhard}
}

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