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Synthesis and Application of 4′-C-Alkylated Uridines as Probes for Uracil-DNA Glycosylase

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2005

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Rangam, Gopinath
Rudinger, Nicolas Z.
Müller, H. Martin

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https://doi.org/10.1055/s-2005-865328
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Synthesis. 2005, 2005(9), pp. 1467-1472. ISSN 0039-7881. eISSN 1437-210X. Available under: doi: 10.1055/s-2005-865328

Zusammenfassung

The development of new synthetic probes to study the mechanism of Uracil-DNA glycosylase is described. 4′-C-Alkylated 2′-deoxyuridines were synthesized and incorporated site-specifically into oligonucleotides. These compounds were subsequently employed in functional studies of the enzyme and proved to be functional competent.

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540 Chemie

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ISO 690RANGAM, Gopinath, Nicolas Z. RUDINGER, H. Martin MÜLLER, Andreas MARX, 2005. Synthesis and Application of 4′-C-Alkylated Uridines as Probes for Uracil-DNA Glycosylase. In: Synthesis. 2005, 2005(9), pp. 1467-1472. ISSN 0039-7881. eISSN 1437-210X. Available under: doi: 10.1055/s-2005-865328
BibTex
@article{Rangam2005Synth-34045,
  year={2005},
  doi={10.1055/s-2005-865328},
  title={Synthesis and Application of 4′-C-Alkylated Uridines as Probes for Uracil-DNA Glycosylase},
  number={9},
  volume={2005},
  issn={0039-7881},
  journal={Synthesis},
  pages={1467--1472},
  author={Rangam, Gopinath and Rudinger, Nicolas Z. and Müller, H. Martin and Marx, Andreas}
}
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