@article{Neupert2009-11Conse-28917,
  year={2009},
  doi={10.1111/j.1471-4159.2009.06361.x},
  title={Conservation of the function counts : homologous neurons express sequence-related neuropeptides that originate from different genes},
  number={3},
  volume={111},
  issn={0022-3042},
  journal={Journal of Neurochemistry},
  pages={757--765},
  author={Neupert, Susanne and Huetteroth, Wolf and Schachtner, Joachim and Predel, Reinhard}
}

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    <dcterms:bibliographicCitation>Journal of neurochemistry ; 111 (2009), 3. - S. 757-765</dcterms:bibliographicCitation>
    <dc:contributor>Schachtner, Joachim</dc:contributor>
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    <dc:contributor>Neupert, Susanne</dc:contributor>
    <dc:creator>Huetteroth, Wolf</dc:creator>
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    <dcterms:title>Conservation of the function counts : homologous neurons express sequence-related neuropeptides that originate from different genes</dcterms:title>
    <dcterms:abstract xml:lang="eng">By means of single-cell matrix assisted laser desorption/ionization time-of-flight mass spectrometry, we analysed neuropeptide expression in all FXPRLamide/pheromone biosynthesis activating neuropeptide synthesizing neurons of the adult tobacco hawk moth, Manduca sexta. Mass spectra clearly suggest a completely identical processing of the pheromone biosynthesis activating neuropeptide-precursor in the mandibular, maxillary and labial neuromeres of the subesophageal ganglion. Only in the pban-neurons of the labial neuromere, products of two neuropeptide genes, namely the pban-gene and the capa-gene, were detected. Both of these genes expressed, amongst others, sequence-related neuropeptides (extended WFGPRLamides). We speculate that the expression of the two neuropeptide genes is a plesiomorph character typical of moths. A detailed examination of the neuroanatomy and the peptidome of the (two) pban-neurons in the labial neuromere of moths with homologous neurons of different insects indicates a strong conservation of the function of this neuroendocrine system. In other insects, however, the labial neurons either express products of the fxprl-gene or products of the capa-gene. The processing of the respective genes is reduced to extended WFGPRLamides in each case and yields a unique peptidome in the labial cells. Thus, sequence-related messenger molecules are always produced in these cells and it seems that the respective neurons recruited different neuropeptide genes for this motif.</dcterms:abstract>
    <dcterms:issued>2009-11</dcterms:issued>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-09-10T16:27:02Z</dc:date>
    <dc:creator>Predel, Reinhard</dc:creator>
    <dc:contributor>Huetteroth, Wolf</dc:contributor>
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    <dc:creator>Schachtner, Joachim</dc:creator>
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