Publikation: Synthesis of oligonucleotides bearing an arylamine modification in the C8-position of 2'-deoxyguanosine
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2005
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Nucleosides, Nucleotides and Nucleic Acids. 2005, 24(5-7), pp. 691-694. ISSN 1525-7770. eISSN 1532-2335. Available under: doi: 10.1081/NCN-200060267
Zusammenfassung
C8-Arylamine-dG adducts were converted into their corresponding 5′-O-DMTr-3′-O-phosphoramidite-C8-arylamine-dG derivatives. These compounds were used for the automated synthesis of site-specifically modified oligonucleotides. The oligonucleotides were studied for their CD properties, Tm values, and their effects on primer extension assays using human DNA-polymerase β.
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MEIER, Chris, Sonja GRÄSL, Ilka DETMER, Andreas MARX, 2005. Synthesis of oligonucleotides bearing an arylamine modification in the C8-position of 2'-deoxyguanosine. In: Nucleosides, Nucleotides and Nucleic Acids. 2005, 24(5-7), pp. 691-694. ISSN 1525-7770. eISSN 1532-2335. Available under: doi: 10.1081/NCN-200060267BibTex
@article{Meier2005-04Synth-33792,
year={2005},
doi={10.1081/NCN-200060267},
title={Synthesis of oligonucleotides bearing an arylamine modification in the C8-position of 2'-deoxyguanosine},
number={5-7},
volume={24},
issn={1525-7770},
journal={Nucleosides, Nucleotides and Nucleic Acids},
pages={691--694},
author={Meier, Chris and Gräsl, Sonja and Detmer, Ilka and Marx, Andreas}
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<dcterms:abstract xml:lang="eng">C8-Arylamine-dG adducts were converted into their corresponding 5′-O-DMTr-3′-O-phosphoramidite-C8-arylamine-dG derivatives. These compounds were used for the automated synthesis of site-specifically modified oligonucleotides. The oligonucleotides were studied for their CD properties, T<sub>m</sub> values, and their effects on primer extension assays using human DNA-polymerase β.</dcterms:abstract>
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