Synthesis of oligonucleotides bearing an arylamine modification in the C8-position of 2'-deoxyguanosine

Meier, Chris; Gräsl, Sonja; Detmer, Ilka; Marx, Andreas

Synthesis of oligonucleotides bearing an arylamine modification in the C8-position of 2'-deoxyguanosine

Dateien

Meier_0-329741.pdf(301.15 KB)

Datum

2005

Autor:innen

Meier, Chris

Gräsl, Sonja

Detmer, Ilka

Marx, Andreas

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Nucleosides, Nucleotides and Nucleic Acids ; 24 (2005), 5-7. - S. 691-694. - ISSN 1525-7770. - eISSN 1532-2335

Zusammenfassung

C8-Arylamine-dG adducts were converted into their corresponding 5′-O-DMTr-3′-O-phosphoramidite-C8-arylamine-dG derivatives. These compounds were used for the automated synthesis of site-specifically modified oligonucleotides. The oligonucleotides were studied for their CD properties, T_m values, and their effects on primer extension assays using human DNA-polymerase β.

Fachgebiet (DDC)

540 Chemie

Zitieren

ISO 690

MEIER, Chris, Sonja GRÄSL, Ilka DETMER, Andreas MARX, 2005. Synthesis of oligonucleotides bearing an arylamine modification in the C8-position of 2'-deoxyguanosine. In: Nucleosides, Nucleotides and Nucleic Acids. 24(5-7), pp. 691-694. ISSN 1525-7770. eISSN 1532-2335. Available under: doi: 10.1081/NCN-200060267

BibTex

@article{Meier2005-04Synth-33792,
  year={2005},
  doi={10.1081/NCN-200060267},
  title={Synthesis of oligonucleotides bearing an arylamine modification in the C8-position of 2'-deoxyguanosine},
  number={5-7},
  volume={24},
  issn={1525-7770},
  journal={Nucleosides, Nucleotides and Nucleic Acids},
  pages={691--694},
  author={Meier, Chris and Gräsl, Sonja and Detmer, Ilka and Marx, Andreas}
}

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Universitätsbibliographie

Ja