@article{Cima2004-12-20Intes-14282,
  year={2004},
  doi={10.1084/jem.20031958},
  title={Intestinal epithelial cells synthesize glucocorticoids and regulate T cell activation},
  number={12},
  volume={200},
  issn={0022-1007},
  journal={Journal of Experimental Medicine},
  pages={1635--1646},
  author={Cima, Igor and Corazza, Nadia and Dick, Bernhard and Fuhrer, Andrea and Herren, Simon and Jakob, Sabine and Ayuni, Erick and Mueller, Christoph and Brunner, Thomas}
}

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/14282">
    <dc:creator>Dick, Bernhard</dc:creator>
    <dc:contributor>Dick, Bernhard</dc:contributor>
    <dc:contributor>Corazza, Nadia</dc:contributor>
    <dc:creator>Jakob, Sabine</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Brunner, Thomas</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/14282/2/2004_Cima-JEM_1204.pdf"/>
    <dc:language>eng</dc:language>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Mueller, Christoph</dc:creator>
    <dcterms:issued>2004-12-20</dcterms:issued>
    <dcterms:abstract xml:lang="eng">Glucocorticoids (GCs) are important steroid hormones with widespread activities in metabolism, development, and immune regulation. The adrenal glands are the major source of GCs and release these hormones in response to psychological and immunological stress. However, there is increasing evidence that GCs may also be synthesized by nonadrenal tissues. Here, we report that the intestinal mucosa expresses steroidogenic enzymes and releases the GC corticosterone in response to T cell activation. T cell activation causes an increase in the intestinal expression of the steroidogenic enzymes required for GC synthesis. In situ hybridization analysis revealed that these enzymes are confined to the crypt region of the intestinal epithelial layer. Surprisingly, in situ–produced GCs exhibit both an inhibitory and a costimulatory role on intestinal T cell activation. In the absence of intestinal GCs in vivo, activation by anti-CD3 injection resulted in reduced CD69 expression and interferon- gamma production by intestinal T cells, whereas activation by viral infection led to increased T cell activation. We conclude that the intestinal mucosa is a potent source of immunoregulatory GCs.</dcterms:abstract>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-20T10:18:11Z</dcterms:available>
    <dcterms:bibliographicCitation>First publ. in: Journal of Experimental Medicine ; 200 (2004), 12. - pp. 1635-1646</dcterms:bibliographicCitation>
    <dc:contributor>Fuhrer, Andrea</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
    <dc:creator>Fuhrer, Andrea</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Cima, Igor</dc:creator>
    <dc:creator>Corazza, Nadia</dc:creator>
    <dcterms:title>Intestinal epithelial cells synthesize glucocorticoids and regulate T cell activation</dcterms:title>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-20T10:18:11Z</dc:date>
    <dc:creator>Ayuni, Erick</dc:creator>
    <dc:creator>Brunner, Thomas</dc:creator>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14282"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/14282/2/2004_Cima-JEM_1204.pdf"/>
    <dc:contributor>Herren, Simon</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:contributor>Cima, Igor</dc:contributor>
    <dc:contributor>Ayuni, Erick</dc:contributor>
    <dc:contributor>Jakob, Sabine</dc:contributor>
    <dc:creator>Herren, Simon</dc:creator>
    <dc:contributor>Mueller, Christoph</dc:contributor>
  </rdf:Description>
</rdf:RDF>