Progress and Prospects for Endophenotypes for Schizophrenia in the Time of Genomics, Epigenetics, Oscillatory Brain Dynamics, and the Research Domain Criteria

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2016
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The Neurobiology of Schizophrenia / Abel, Ted et al. (ed.). - Amsterdam : Elsevier, Academic Press, 2016. - pp. 17-38. - ISBN 978-0-12-801829-3
Abstract
Endophenotypes are biological or psychological phenomena of a disorder believed to be in the causal chain between genetic contributions to a disorder and diagnosable symptoms of psychopathology. Decades of psychophysiological research have identified a variety of established and candidate endophenotypes for schizophrenia without offering much insight into genetic contributions to the disorder and without substantially improving the understanding of the complex psychopathology. This chapter surveys issues surrounding the pursuit of endophenotypes for schizophrenia and some of the findings being established. Diverse lines of research not only complement each other in indicating fundamental characteristics of psychopathology (such as dimensional aspects) but also suggest that progress in understanding the nature and origins of schizophrenia would benefit from a new perspective on psychopathology research. The NIMH Research Domain Criteria initiative offers a promising framework for identifying factors contributing to schizophrenia.
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150 Psychology
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ISO 690MILLER, Gregory A., Brigitte ROCKSTROH, 2016. Progress and Prospects for Endophenotypes for Schizophrenia in the Time of Genomics, Epigenetics, Oscillatory Brain Dynamics, and the Research Domain Criteria. In: ABEL, Ted, ed. and others. The Neurobiology of Schizophrenia. Amsterdam:Elsevier, Academic Press, pp. 17-38. ISBN 978-0-12-801829-3. Available under: doi: 10.1016/B978-0-12-801829-3.00010-0
BibTex
@incollection{Miller2016Progr-40851,
  year={2016},
  doi={10.1016/B978-0-12-801829-3.00010-0},
  title={Progress and Prospects for Endophenotypes for Schizophrenia in the Time of Genomics, Epigenetics, Oscillatory Brain Dynamics, and the Research Domain Criteria},
  isbn={978-0-12-801829-3},
  publisher={Elsevier, Academic Press},
  address={Amsterdam},
  booktitle={The Neurobiology of Schizophrenia},
  pages={17--38},
  editor={Abel, Ted},
  author={Miller, Gregory A. and Rockstroh, Brigitte}
}
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