@article{Srulijes2017DualT-55583,
  year={2017},
  doi={10.1155/2017/8582740},
  title={Dual-Task Performance in GBA Parkinson's Disease},
  issn={2090-8083},
  journal={Parkinson's disease},
  author={Srulijes, Karin and Brockmann, Kathrin and Ogbamicael, Senait and Hobert, Markus A. and Hauser, Ann-Kathrin and Schulte, Claudia and Fritzen, Jasmin and Schwenk, Michael and Gasser, Thomas and Maetzler, Walter},
  note={Article Number: 8582740}
}

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    <dc:rights>Attribution 4.0 International</dc:rights>
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    <dc:creator>Schwenk, Michael</dc:creator>
    <dc:creator>Maetzler, Walter</dc:creator>
    <dc:contributor>Srulijes, Karin</dc:contributor>
    <dc:contributor>Schwenk, Michael</dc:contributor>
    <dc:creator>Fritzen, Jasmin</dc:creator>
    <dcterms:abstract xml:lang="eng">Introduction. Parkinson’s disease patients carrying a heterozygous mutation in the gene glucocerebrosidase (GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson’s disease (iPD) patients, but the mechanisms behind this observation are not well understood. Successful dual tasking (DT) requires a smooth integration of motor and nonmotor operations. This study compared the DT performances between GBA-PD and iPD patients. Methods. Eleven GBA-PD patients (p.N370S, p.L444P) and eleven matched iPD patients were included. Clinical characterization included a motor score (Unified PD Rating Scale-III, UPDRS-III) and nonmotor scores (Montreal Cognitive Assessment, MoCA, and Beck’s Depression Inventory). Quantitative gait analysis during the single-task (ST) and DT assessments was performed using a wearable sensor unit. These parameters corrected for UPDRS and MoCA were then compared between the groups. Results. Under the DT condition “walking while checking boxes,” GBA-PD patients showed slower gait and box-checking speeds than iPD patients. GBA-PD and iPD patients did not show significant differences regarding dual-task costs. Conclusion. This pilot study suggests that DT performance with a secondary motor task is worse in GBA-PD than in iPD patients. This finding may be associated with the known enhanced motor and cognitive deficits in GBA-PD compared to iPD and should motivate further studies.</dcterms:abstract>
    <dc:creator>Schulte, Claudia</dc:creator>
    <dc:contributor>Schulte, Claudia</dc:contributor>
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    <dc:creator>Ogbamicael, Senait</dc:creator>
    <dc:contributor>Brockmann, Kathrin</dc:contributor>
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    <dc:creator>Gasser, Thomas</dc:creator>
    <dc:contributor>Hauser, Ann-Kathrin</dc:contributor>
    <dcterms:title>Dual-Task Performance in GBA Parkinson's Disease</dcterms:title>
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    <dc:creator>Hauser, Ann-Kathrin</dc:creator>
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    <dc:contributor>Gasser, Thomas</dc:contributor>
    <dc:creator>Srulijes, Karin</dc:creator>
    <dc:contributor>Ogbamicael, Senait</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:contributor>Fritzen, Jasmin</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-11-18T11:21:06Z</dcterms:available>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-11-18T11:21:06Z</dc:date>
    <dc:contributor>Hobert, Markus A.</dc:contributor>
    <dc:contributor>Maetzler, Walter</dc:contributor>
    <dc:creator>Brockmann, Kathrin</dc:creator>
    <dc:creator>Hobert, Markus A.</dc:creator>
    <dcterms:issued>2017</dcterms:issued>
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