Effects of Daytime Dry Fasting on Hydration, Glucose Metabolism and Circadian Phase : A Prospective Exploratory Cohort Study in Bahá'í Volunteers

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2021
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Koppold-Liebscher, Daniela A.
Klatte, Caroline
Demmrich, Sarah
Schwarz, Julia
Kandil, Farid I.
Steckhan, Nico
Ring, Raphaela
Kessler, Christian S.
Jeitler, Michael
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Frontiers in Nutrition. Frontiers Media. 2021, 8, 662310. eISSN 2296-861X. Available under: doi: 10.3389/fnut.2021.662310
Zusammenfassung

Background: Religiously motivated Bahá'í fasting (BF) is a form of intermittent dry fasting celebrated by abstaining from food and drinks during daylight hours every year in March for 19 consecutive days.

Aim: To test the safety and effects of BF on hydration, metabolism, and the circadian clock.

Methods: Thirty-four healthy Bahá'í volunteers (15 women) participated in this prospective, exploratory cohort study. Laboratory examinations were carried out in four study visits: before fasting (V0), in the third week of fasting (V1) as well as 3 weeks (V3) and 3 months (V4) after fasting. Data collection included blood and urine samples, anthropometric measurements and bioelectrical impedance analysis. At V0 and V1, 24- and 12-hour urine and serum osmolality were measured. At V0-V2, alterations in the circadian clock phase were monitored in 16 participants. Our study was augmented by an additional survey with 144 healthy Bahá'í volunteers filling out questionnaires and with subgroups attending metabolic measurements (n = 11) and qualitative interviews (n = 13), the results of which will be published separately.

Results: Exploratory data analysis revealed that serum osmolality (n = 34, p < 0.001) and 24-hour urine osmolality (n = 34, p = 0.003) decreased during daytime fasting but remained largely within the physiological range and returned to pre-fasting levels during night hours. BMI (body mass index), total body fat mass, and resting metabolic rate decreased during fasting (n = 34, p < 0.001), while body cell mass and body water appeared unchanged. The circadian phase estimated by transcript biomarkers of blood monocytes advanced by 1.1 h (n = 16, p < 0.005) during fasting and returned to pre-fasting values 3 weeks after fasting. Most observed changes were not detectable anymore 3 months after fasting.

Conclusions: Results indicate that BF (Bahá'í fasting) is safe, has no negative effects on hydration, can improve fat metabolism and can cause transient phase shifts of circadian rhythms.

Trial Registration:https://www.clinicaltrials.gov/, identifier: NCT03443739.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
300 Sozialwissenschaften, Soziologie
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hydration, religious, intermittent fasting, chronobiology, water deprivation, time-restricted eating, fasting, diurnal fasting
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ISO 690KOPPOLD-LIEBSCHER, Daniela A., Caroline KLATTE, Sarah DEMMRICH, Julia SCHWARZ, Farid I. KANDIL, Nico STECKHAN, Raphaela RING, Christian S. KESSLER, Michael JEITLER, Clemens EISENMANN, 2021. Effects of Daytime Dry Fasting on Hydration, Glucose Metabolism and Circadian Phase : A Prospective Exploratory Cohort Study in Bahá'í Volunteers. In: Frontiers in Nutrition. Frontiers Media. 2021, 8, 662310. eISSN 2296-861X. Available under: doi: 10.3389/fnut.2021.662310
BibTex
@article{KoppoldLiebscher2021Effec-54998,
  year={2021},
  doi={10.3389/fnut.2021.662310},
  title={Effects of Daytime Dry Fasting on Hydration, Glucose Metabolism and Circadian Phase : A Prospective Exploratory Cohort Study in Bahá'í Volunteers},
  volume={8},
  journal={Frontiers in Nutrition},
  author={Koppold-Liebscher, Daniela A. and Klatte, Caroline and Demmrich, Sarah and Schwarz, Julia and Kandil, Farid I. and Steckhan, Nico and Ring, Raphaela and Kessler, Christian S. and Jeitler, Michael and Eisenmann, Clemens},
  note={Article Number: 662310}
}
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