Publikation:

Identification of Novel Quadruplex Ligands from Small Molecule Libraries by FRET-Based High-Throughput Screening

Lade...
Vorschaubild

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2011

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

ChemBioChem. 2011, 12(9), pp. 1422-1426. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201100094

Zusammenfassung

Guanosine-rich nucleic acid sequences can fold into noncanonical higher order structures named G quadruplexes (GQPs). These folds are stabilized by eight Hoogsteen hydrogen bonds per tetrad and p–p stacking interactions between the tetrads.[1] Due to their stability quadruplexes occurring in promoter regions of genes [2] or at the telomeric ends of eukaryotic chromosomes have been suspected to play regulatory roles in gene expression and cell cycle control. [3] In addition, compounds binding to quadruplexes have been studied intensively because of their potential in anticancer treatment.[4] Telomeric DNA comprises thousands of double-stranded tandem repeats of the sequence d(GGGTTA)[5] and a single stranded G rich 3’ overhang of about 100–200 nucleotides.[6] During the life time of a somatic cell telomeres are permanently shortened because of the end-replication problem. At a critical length this leads to induction of cell cycle arrest or even to cell death. [7] However, in about 80–85% of all cancer cells this problem is circumvented as the telomere length is maintained by activation of telomerase,[8] an enzyme that is inactive in somatic cells. [9] By addition of telomeric repeats to the single stranded 3’ overhang, cancer cells can become immortal.[10] Several compounds have been shown to induce quadruplexes, disturbing the telomeric structure and function providing a promising anticancer treatment.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

small molecules, human telomeres, high-throughput screening, FRET

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690BENZ, Armin, Vijay SINGH, Thomas U. MAYER, Jörg S. HARTIG, 2011. Identification of Novel Quadruplex Ligands from Small Molecule Libraries by FRET-Based High-Throughput Screening. In: ChemBioChem. 2011, 12(9), pp. 1422-1426. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201100094
BibTex
@article{Benz2011-06-14Ident-13689,
  year={2011},
  doi={10.1002/cbic.201100094},
  title={Identification of Novel Quadruplex Ligands from Small Molecule Libraries by FRET-Based High-Throughput Screening},
  number={9},
  volume={12},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={1422--1426},
  author={Benz, Armin and Singh, Vijay and Mayer, Thomas U. and Hartig, Jörg S.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/13689">
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-06-17T07:33:07Z</dcterms:available>
    <dc:language>eng</dc:language>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dcterms:issued>2011-06-14</dcterms:issued>
    <dc:rights>terms-of-use</dc:rights>
    <dc:creator>Hartig, Jörg S.</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-06-17T07:33:07Z</dc:date>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <dc:creator>Singh, Vijay</dc:creator>
    <dcterms:title>Identification of Novel Quadruplex Ligands from Small Molecule Libraries by FRET-Based High-Throughput Screening</dcterms:title>
    <dc:contributor>Benz, Armin</dc:contributor>
    <dc:contributor>Hartig, Jörg S.</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <dcterms:abstract xml:lang="eng">Guanosine-rich nucleic acid sequences can fold into noncanonical higher order structures named G quadruplexes (GQPs). These folds are stabilized by eight Hoogsteen hydrogen bonds per tetrad and p–p stacking interactions between the tetrads.[1] Due to their stability quadruplexes occurring in promoter regions of genes [2] or at the telomeric ends of eukaryotic chromosomes have been suspected to play regulatory roles in gene expression and cell cycle control. [3] In addition, compounds binding to quadruplexes have been studied intensively because of their potential in anticancer treatment.[4] Telomeric DNA comprises thousands of double-stranded tandem repeats of the sequence d(GGGTTA)[5] and a single stranded G rich 3’ overhang of about 100–200 nucleotides.[6] During the life time of a somatic cell telomeres are permanently shortened because of the end-replication problem. At a critical length this leads to induction of cell cycle arrest or even to cell death. [7] However, in about 80–85% of all cancer cells this problem is circumvented as the telomere length is maintained by activation of telomerase,[8] an enzyme that is inactive in somatic cells. [9] By addition of telomeric repeats to the single stranded 3’ overhang, cancer cells can become immortal.[10] Several compounds have been shown to induce quadruplexes, disturbing the telomeric structure and function providing a promising anticancer treatment.</dcterms:abstract>
    <dcterms:bibliographicCitation>ChemBioChem ; 12 (2011), 9. - S. 1422-1426</dcterms:bibliographicCitation>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/13689"/>
    <dc:contributor>Singh, Vijay</dc:contributor>
    <dc:contributor>Mayer, Thomas U.</dc:contributor>
    <dc:creator>Benz, Armin</dc:creator>
    <dc:creator>Mayer, Thomas U.</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen