Publikation:

In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo

Lade...
Vorschaubild

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2012

Autor:innen

Musuyu Muganza, Désiré
Nzunzu Lami, José
Mesia, Gauthier Kahunu
Kambu, Oscar K.
Tona, Gaston L.
Cimanga, Kanyanga
Cos, Paul
Maes, Louis J.R.M.
Apers, Sandra
et al.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Journal of ethnopharmacology. Elsevier. 2012, 141(1), pp. 301-308. ISSN 0378-8741. eISSN 1872-7573. Available under: doi: 10.1016/j.jep.2012.02.035

Zusammenfassung

Ethnopharmacological relevance
The antiprotozoal and cytotoxic activity of the aqueous extracts from 33 medicinal plants, used by traditional healers for the treatment of various parasitic diseases and collected after an ethnopharmacological inventory conducted in the Bolongo area, Bandundu province in DR Congo, was evaluated.

Materials and methods
Decoctions were prepared, lyophilized and evaluated for in vitro antiprotozoal activity against Trypanosoma b. brucei, Trypanosoma cruzi, Leishmania infantum, and the chloroquine- and pyrimethamine-resistant K1 strain of Plasmodium falciparum. Cytotoxicity against MRC-5 cells was included to assess selectivity of activity.

Results
Most of the tested extracts exhibited pronounced (IC50 ≤ 5 μg/ml) or good (5 < IC50 ≤ 10 μg/ml) antiprotozoal activity against one or more of the selected protozoa. A total of 19 plant extracts inhibited Trypanosoma b. brucei, especially the extract from Isolona hexaloba stem bark (IC50 = 1.95 μg/ml, SI = 16.5); 8 plant extracts were active against Trypanosoma cruzi, the extracts from Enanatia chlorantha stem bark and Quassia africana root bark being the most active with IC50 values of 1.87 and 1.88 μg/ml, respectively (SI = 3.0 and 3.3, respectively); 8 plant extracts showed activity against Leishmania infantum, with extracts from Napoleona vogelii stem bark and Quassia africana root bark as the most active with IC50 values of 5.66 and 5.04 μg/ml (SI = 11.3 and 1.2). Finally, 9 plant extracts inhibited Plasmodium falciparum K1 with the extracts from Quassia africana (root bark and stem bark) being the most active ones with IC50 values of 0.46 and 1.27 μg/ml (SI = 13.7 and 13.6). Extracts from Enantia chlorantha stem bark, Piptadeniastrum africanum stem bark and Quassia africana root bark were cytotoxic for MRC-5 cells (CC50 < 10 μg/ml).

Conclusions
These results can partly support and justify the traditional use of some of these plant species for the treatment of parasitic diseases.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Medicinal plants, Aqueous extracts, Antiprotozoal activity, Cytotoxicity, DR Congo

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690MUSUYU MUGANZA, Désiré, Barbara FRUTH, José NZUNZU LAMI, Gauthier Kahunu MESIA, Oscar K. KAMBU, Gaston L. TONA, Kanyanga CIMANGA, Paul COS, Louis J.R.M. MAES, Sandra APERS, 2012. In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo. In: Journal of ethnopharmacology. Elsevier. 2012, 141(1), pp. 301-308. ISSN 0378-8741. eISSN 1872-7573. Available under: doi: 10.1016/j.jep.2012.02.035
BibTex
@article{MusuyuMuganza2012-05-07vitro-56972,
  year={2012},
  doi={10.1016/j.jep.2012.02.035},
  title={In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo},
  number={1},
  volume={141},
  issn={0378-8741},
  journal={Journal of ethnopharmacology},
  pages={301--308},
  author={Musuyu Muganza, Désiré and Fruth, Barbara and Nzunzu Lami, José and Mesia, Gauthier Kahunu and Kambu, Oscar K. and Tona, Gaston L. and Cimanga, Kanyanga and Cos, Paul and Maes, Louis J.R.M. and Apers, Sandra}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/56972">
    <dc:contributor>Cimanga, Kanyanga</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-23T16:04:50Z</dc:date>
    <dc:contributor>Mesia, Gauthier Kahunu</dc:contributor>
    <dc:creator>Cimanga, Kanyanga</dc:creator>
    <dc:creator>Maes, Louis J.R.M.</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Kambu, Oscar K.</dc:contributor>
    <dc:creator>Kambu, Oscar K.</dc:creator>
    <dcterms:abstract xml:lang="eng">Ethnopharmacological relevance&lt;br /&gt;The antiprotozoal and cytotoxic activity of the aqueous extracts from 33 medicinal plants, used by traditional healers for the treatment of various parasitic diseases and collected after an ethnopharmacological inventory conducted in the Bolongo area, Bandundu province in DR Congo, was evaluated.&lt;br /&gt;&lt;br /&gt;Materials and methods&lt;br /&gt;Decoctions were prepared, lyophilized and evaluated for in vitro antiprotozoal activity against Trypanosoma b. brucei, Trypanosoma cruzi, Leishmania infantum, and the chloroquine- and pyrimethamine-resistant K1 strain of Plasmodium falciparum. Cytotoxicity against MRC-5 cells was included to assess selectivity of activity.&lt;br /&gt;&lt;br /&gt;Results&lt;br /&gt;Most of the tested extracts exhibited pronounced (IC50 ≤ 5 μg/ml) or good (5 &lt; IC50 ≤ 10 μg/ml) antiprotozoal activity against one or more of the selected protozoa. A total of 19 plant extracts inhibited Trypanosoma b. brucei, especially the extract from Isolona hexaloba stem bark (IC50 = 1.95 μg/ml, SI = 16.5); 8 plant extracts were active against Trypanosoma cruzi, the extracts from Enanatia chlorantha stem bark and Quassia africana root bark being the most active with IC50 values of 1.87 and 1.88 μg/ml, respectively (SI = 3.0 and 3.3, respectively); 8 plant extracts showed activity against Leishmania infantum, with extracts from Napoleona vogelii stem bark and Quassia africana root bark as the most active with IC50 values of 5.66 and 5.04 μg/ml (SI = 11.3 and 1.2). Finally, 9 plant extracts inhibited Plasmodium falciparum K1 with the extracts from Quassia africana (root bark and stem bark) being the most active ones with IC50 values of 0.46 and 1.27 μg/ml (SI = 13.7 and 13.6). Extracts from Enantia chlorantha stem bark, Piptadeniastrum africanum stem bark and Quassia africana root bark were cytotoxic for MRC-5 cells (CC50 &lt; 10 μg/ml).&lt;br /&gt;&lt;br /&gt;Conclusions&lt;br /&gt;These results can partly support and justify the traditional use of some of these plant species for the treatment of parasitic diseases.</dcterms:abstract>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:creator>Nzunzu Lami, José</dc:creator>
    <dc:creator>Cos, Paul</dc:creator>
    <dc:creator>Fruth, Barbara</dc:creator>
    <dc:contributor>Apers, Sandra</dc:contributor>
    <dc:creator>Apers, Sandra</dc:creator>
    <dc:language>eng</dc:language>
    <dc:contributor>Musuyu Muganza, Désiré</dc:contributor>
    <dcterms:title>In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo</dcterms:title>
    <dc:rights>terms-of-use</dc:rights>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:issued>2012-05-07</dcterms:issued>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-03-23T16:04:50Z</dcterms:available>
    <dc:creator>Tona, Gaston L.</dc:creator>
    <dc:creator>Musuyu Muganza, Désiré</dc:creator>
    <dc:contributor>Cos, Paul</dc:contributor>
    <dc:creator>Mesia, Gauthier Kahunu</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Tona, Gaston L.</dc:contributor>
    <dc:contributor>Nzunzu Lami, José</dc:contributor>
    <dc:contributor>Fruth, Barbara</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/56972"/>
    <dc:contributor>Maes, Louis J.R.M.</dc:contributor>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Begutachtet
Ja
Diese Publikation teilen