Publikation:

Nucleocytoplasmic transport in apoptosis

Vorschaubild

Dateien

May01.pdf
May01.pdfGröße: 220.61 KBDownloads: 256

Datum

2005

Autor:innen

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-182468
DOI (zitierfähiger Link)
https://doi.org/10.1038/sj.cdd.4401626
ArXiv-ID

Internationale Patentnummer

Link zur Lizenz
Urheberrechtlich geschützt

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Green

Sammlungen

Biologie: Publikationen
Zukunftskolleg: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Cell Death and Differentiation. 2005, 12(10), pp. 1263-1276. ISSN 1350-9047. Available under: doi: 10.1038/sj.cdd.4401626

Zusammenfassung

The apoptotic demolition of the nucleus is accomplished by diverse proapoptotic factors, most of which are activated in the cytoplasm and gain access to the nucleoplasm during the cell death process. The nucleus is also the main target for genotoxic insult, a potent apoptotic trigger. Signals generated in the nucleus by DNA damage have to propagate to all cellular compartments to ensure the coordinated execution of cell demise. The nucleocytoplasmic shuttling of signalling and execution factors is thus an integral part of the apoptotic programme. Several proteins implicated in apoptotic cell death have been shown to migrate in and out of the nucleus following apoptosis induction. This review summarises the current knowledge on nucleocytoplasmic trafficking of apoptosis-relevant proteins. The effects of apoptosis induction on the nucleocytoplasmic transport machinery are also discussed. Finally, a potential role of nuclear transport as a critical control point of the apoptotic signal cascade is proposed.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690FERRANDO-MAY, Elisa, 2005. Nucleocytoplasmic transport in apoptosis. In: Cell Death and Differentiation. 2005, 12(10), pp. 1263-1276. ISSN 1350-9047. Available under: doi: 10.1038/sj.cdd.4401626
BibTex
@article{FerrandoMay2005-10Nucle-18246,
  year={2005},
  doi={10.1038/sj.cdd.4401626},
  title={Nucleocytoplasmic transport in apoptosis},
  number={10},
  volume={12},
  issn={1350-9047},
  journal={Cell Death and Differentiation},
  pages={1263--1276},
  author={Ferrando-May, Elisa}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/18246">
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/18246"/>
    <dc:contributor>Ferrando-May, Elisa</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:language>eng</dc:language>
    <dc:creator>Ferrando-May, Elisa</dc:creator>
    <dcterms:abstract xml:lang="eng">The apoptotic demolition of the nucleus is accomplished by diverse proapoptotic factors, most of which are activated in the cytoplasm and gain access to the nucleoplasm during the cell death process. The nucleus is also the main target for genotoxic insult, a potent apoptotic trigger. Signals generated in the nucleus by DNA damage have to propagate to all cellular compartments to ensure the coordinated execution of cell demise. The nucleocytoplasmic shuttling of signalling and execution factors is thus an integral part of the apoptotic programme. Several proteins implicated in apoptotic cell death have been shown to migrate in and out of the nucleus following apoptosis induction. This review summarises the current knowledge on nucleocytoplasmic trafficking of apoptosis-relevant proteins. The effects of apoptosis induction on the nucleocytoplasmic transport machinery are also discussed. Finally, a potential role of nuclear transport as a critical control point of the apoptotic signal cascade is proposed.</dcterms:abstract>
    <dcterms:bibliographicCitation>First publ. in: Cell Death and Differentiation ; 12 (2005), 10. - S. 1263-1276</dcterms:bibliographicCitation>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-03-19T12:48:06Z</dcterms:available>
    <dcterms:title>Nucleocytoplasmic transport in apoptosis</dcterms:title>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/18246/2/May01.pdf"/>
    <dcterms:issued>2005-10</dcterms:issued>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-03-19T12:48:06Z</dc:date>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/18246/2/May01.pdf"/>
    <dc:rights>terms-of-use</dc:rights>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen