Publikation:

New pairings and deorphanization among the atypical chemokine receptor family : physiological and clinical relevance

Lade...
Vorschaubild

Dateien

Szpakowska_2-cvopssjq0lpj1.pdf
Szpakowska_2-cvopssjq0lpj1.pdfGröße: 2.22 MBDownloads: 48

Datum

2023

Autor:innen

Szpakowska, Martyna
D’Uonnolo, Giulia
Luís, Rafael
Alonso Bartolomé, Ana
Thelen, Marcus
Chevigné, Andy

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Link zur Lizenz

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Gold
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Frontiers in Immunology. Frontiers. 2023, 14, 1133394. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2023.1133394

Zusammenfassung

Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands. They do, however, play a crucial regulatory role in chemokine biology by capturing, scavenging or transporting chemokines, thereby regulating their availability and signaling through classical chemokine receptors. ACKRs add thus another layer of complexity to the intricate chemokine–receptor interaction network. Recently, targeted approaches and screening programs aiming at reassessing chemokine activity towards ACKRs identified several new pairings such as the dimeric CXCL12 with ACKR1, CXCL2, CXCL10 and CCL26 with ACKR2, the viral broad-spectrum chemokine vCCL2/vMIP-II, a range of opioid peptides and PAMP-12 with ACKR3 as well as CCL20 and CCL22 with ACKR4. Moreover, GPR182 (ACKR5) has been lately proposed as a new promiscuous atypical chemokine receptor with scavenging activity notably towards CXCL9, CXCL10, CXCL12 and CXCL13. Altogether, these findings reveal new degrees of complexity of the chemokine network and expand the panel of ACKR ligands and regulatory functions. In this minireview, we present and discuss these new pairings, their physiological and clinical relevance as well as the opportunities they open for targeting ACKRs in innovative therapeutic strategies.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

ACKR1, ACKR2, ACKR3, ACKR4, ACKR5, D6, CXCR7, GPR182

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690SZPAKOWSKA, Martyna, Giulia D’UONNOLO, Rafael LUÍS, Ana ALONSO BARTOLOMÉ, Marcus THELEN, Daniel F. LEGLER, Andy CHEVIGNÉ, 2023. New pairings and deorphanization among the atypical chemokine receptor family : physiological and clinical relevance. In: Frontiers in Immunology. Frontiers. 2023, 14, 1133394. eISSN 1664-3224. Available under: doi: 10.3389/fimmu.2023.1133394
BibTex
@article{Szpakowska2023pairi-66903,
  year={2023},
  doi={10.3389/fimmu.2023.1133394},
  title={New pairings and deorphanization among the atypical chemokine receptor family : physiological and clinical relevance},
  volume={14},
  journal={Frontiers in Immunology},
  author={Szpakowska, Martyna and D’Uonnolo, Giulia and Luís, Rafael and Alonso Bartolomé, Ana and Thelen, Marcus and Legler, Daniel F. and Chevigné, Andy},
  note={Article Number: 1133394}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/66903">
    <dc:creator>Alonso Bartolomé, Ana</dc:creator>
    <dc:creator>Legler, Daniel F.</dc:creator>
    <dc:contributor>D’Uonnolo, Giulia</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Thelen, Marcus</dc:contributor>
    <dc:creator>Luís, Rafael</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/66903/1/Szpakowska_2-cvopssjq0lpj1.pdf"/>
    <dc:creator>D’Uonnolo, Giulia</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2023-05-16T06:51:52Z</dc:date>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Szpakowska, Martyna</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2023-05-16T06:51:52Z</dcterms:available>
    <dc:contributor>Alonso Bartolomé, Ana</dc:contributor>
    <dcterms:issued>2023</dcterms:issued>
    <dc:rights>Attribution 4.0 International</dc:rights>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/66903"/>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/>
    <dc:contributor>Szpakowska, Martyna</dc:contributor>
    <dc:contributor>Luís, Rafael</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Thelen, Marcus</dc:creator>
    <dcterms:title>New pairings and deorphanization among the atypical chemokine receptor family : physiological and clinical relevance</dcterms:title>
    <dc:contributor>Chevigné, Andy</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:creator>Chevigné, Andy</dc:creator>
    <dc:contributor>Legler, Daniel F.</dc:contributor>
    <dcterms:abstract>Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands. They do, however, play a crucial regulatory role in chemokine biology by capturing, scavenging or transporting chemokines, thereby regulating their availability and signaling through classical chemokine receptors. ACKRs add thus another layer of complexity to the intricate chemokine–receptor interaction network. Recently, targeted approaches and screening programs aiming at reassessing chemokine activity towards ACKRs identified several new pairings such as the dimeric CXCL12 with ACKR1, CXCL2, CXCL10 and CCL26 with ACKR2, the viral broad-spectrum chemokine vCCL2/vMIP-II, a range of opioid peptides and PAMP-12 with ACKR3 as well as CCL20 and CCL22 with ACKR4. Moreover, GPR182 (ACKR5) has been lately proposed as a new promiscuous atypical chemokine receptor with scavenging activity notably towards CXCL9, CXCL10, CXCL12 and CXCL13. Altogether, these findings reveal new degrees of complexity of the chemokine network and expand the panel of ACKR ligands and regulatory functions. In this minireview, we present and discuss these new pairings, their physiological and clinical relevance as well as the opportunities they open for targeting ACKRs in innovative therapeutic strategies.</dcterms:abstract>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/66903/1/Szpakowska_2-cvopssjq0lpj1.pdf"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja
Diese Publikation teilen