Publikation:

Major events in the genome evolution of vertebrates : paranome age and size differ considerably between ray-finned fishes and land vertebrates

Lade...
Vorschaubild

Dateien

P152.pdf
P152.pdfGröße: 505.58 KBDownloads: 471

Datum

2004

Autor:innen

Vandepoele, Klaas
Vos, Wouter de
Taylor, John S.
Van der Peer, Yves

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Green
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Proceedings of the National Academy of Sciences. 2004, 101(6), pp. 1638-1643. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.0307968100

Zusammenfassung

It has been suggested that fish have more genes than humans. Whether most of these additional genes originated through a complete (fish-specific) genome duplication or through many lineagespecific tandem gene or smaller block duplications and family expansions continues to be debated. We analyzed the complete genome of the pufferfish Takifugu rubripes (Fugu) and compared it with the paranome of humans. We show that most paralogous genes of Fugu are the result of three complete genome duplications. Both relative and absolute dating of the complete predicted set of protein-coding genes suggest that initial genome duplications, estimated to have occurred at least 600 million years ago, shaped the genome of all vertebrates. In addition, analysis of >150 block duplications in the Fugu genome clearly supports a fish-specific genome muplication (320 million years ago) that coincided with the vast radiation of most modern ray-finned fishes. Unlike the human genome, Fugu contains very few recently duplicated genes; hence, many human genes are much younger than fish genes. This lack of recent gene duplication, or, alternatively, the accelerated rate of gene loss, is possibly one reason for the drastic reduction of the genome size of Fugu observed during the past 100 million years or so, subsequent to the additional genome duplication that ray-finned fishes but not land vertebrates experienced.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690VANDEPOELE, Klaas, Wouter de VOS, John S. TAYLOR, Axel MEYER, Yves VAN DER PEER, 2004. Major events in the genome evolution of vertebrates : paranome age and size differ considerably between ray-finned fishes and land vertebrates. In: Proceedings of the National Academy of Sciences. 2004, 101(6), pp. 1638-1643. ISSN 0027-8424. eISSN 1091-6490. Available under: doi: 10.1073/pnas.0307968100
BibTex
@article{Vandepoele2004-02-10Major-8648,
  year={2004},
  doi={10.1073/pnas.0307968100},
  title={Major events in the genome evolution of vertebrates : paranome age and size differ considerably between ray-finned fishes and land vertebrates},
  number={6},
  volume={101},
  issn={0027-8424},
  journal={Proceedings of the National Academy of Sciences},
  pages={1638--1643},
  author={Vandepoele, Klaas and Vos, Wouter de and Taylor, John S. and Meyer, Axel and Van der Peer, Yves}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/8648">
    <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Vos, Wouter de</dc:creator>
    <dcterms:issued>2004-02-10</dcterms:issued>
    <dc:contributor>Vandepoele, Klaas</dc:contributor>
    <dc:contributor>Meyer, Axel</dc:contributor>
    <dc:language>eng</dc:language>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:45:23Z</dc:date>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:title>Major events in the genome evolution of vertebrates : paranome age and size differ considerably between ray-finned fishes and land vertebrates</dcterms:title>
    <dc:creator>Meyer, Axel</dc:creator>
    <dcterms:abstract xml:lang="eng">It has been suggested that fish have more genes than humans. Whether most of these additional genes originated through a complete (fish-specific) genome duplication or through many lineagespecific tandem gene or smaller block duplications and family expansions continues to be debated. We analyzed the complete genome of the pufferfish Takifugu rubripes (Fugu) and compared it with the paranome of humans. We show that most paralogous genes of Fugu are the result of three complete genome duplications. Both relative and absolute dating of the complete predicted set of protein-coding genes suggest that initial genome duplications, estimated to have occurred at least 600 million years ago, shaped the genome of all vertebrates. In addition, analysis of &gt;150 block duplications in the Fugu genome clearly supports a fish-specific genome muplication (320 million years ago) that coincided with the vast radiation of most modern ray-finned fishes. Unlike the human genome, Fugu contains very few recently duplicated genes; hence, many human genes are much younger than fish genes. This lack of recent gene duplication, or, alternatively, the accelerated rate of gene loss, is possibly one reason for the drastic reduction of the genome size of Fugu observed during the past 100 million years or so, subsequent to the additional genome duplication that ray-finned fishes but not land vertebrates experienced.</dcterms:abstract>
    <dc:format>application/pdf</dc:format>
    <dc:creator>Taylor, John S.</dc:creator>
    <dc:creator>Van der Peer, Yves</dc:creator>
    <dc:contributor>Taylor, John S.</dc:contributor>
    <dc:contributor>Vos, Wouter de</dc:contributor>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/>
    <dc:contributor>Van der Peer, Yves</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8648/1/P152.pdf"/>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/8648"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Vandepoele, Klaas</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/8648/1/P152.pdf"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:45:23Z</dcterms:available>
    <dcterms:bibliographicCitation>First publ. in: Proceedings of the National Academy of Science, 101 (2004), 6, pp. 1638-1643</dcterms:bibliographicCitation>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen