Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene

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2018
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Hemmings, Sian Megan Joanna
Xulu, Khethelo
Malan-Müller, Stefanie
Tromp, Gerard
Seedat, Soraya
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European Union (EU): 323977
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Memo TV - Epigenetic, neural and cognitive memories of traumatic stress and violence
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Scientific Reports. 2018, 8(1), 6714. eISSN 2045-2322. Available under: doi: 10.1038/s41598-018-25066-8
Zusammenfassung

Appetitive aggression is a sub-category of instrumental aggression, characterised by the primary intrinsic enjoyment of aggressive activity. Aggression is heritable, and serotonergic and monoaminergic neurotransmitter systems have been found to contribute to the underlying molecular mechanisms. The aim of this study was to investigate the role that genetic variants in the serotonin transporter (SLC6A4) and monoamine oxidase A (MAOA) genes play in the aetiology of appetitive aggression in South African Xhosa males (n = 290). SLC6A4 5-HTTLPR, rs25531, and STin2 variants, as well as MAOA-uVNTR were investigated for their association with levels of appetitive aggression using Poisson regression analysis. The STin2 VNTR12 allele was found to be associated with increased levels of appetitive aggression (p = 0.003), but with decreased levels of reactive aggression (p = 7 × 10-5). This study is the first to investigate genetic underpinnings of appetitive aggression in a South African population, with preliminary evidence suggesting that SCL6A4 STin2 variants play a role in its aetiology, and may also be important in differentiating between appetitive and reactive aggression. Although the results require replication, they shed some preliminary light on the molecular dichotomy that may underlie the two forms of aggression.

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ISO 690HEMMINGS, Sian Megan Joanna, Khethelo XULU, Jessica SOMMER, Martina HINSBERGER, Stefanie MALAN-MÜLLER, Gerard TROMP, Thomas ELBERT, Roland WEIERSTALL, Soraya SEEDAT, 2018. Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene. In: Scientific Reports. 2018, 8(1), 6714. eISSN 2045-2322. Available under: doi: 10.1038/s41598-018-25066-8
BibTex
@article{Hemmings2018-04-30Appet-42432,
  year={2018},
  doi={10.1038/s41598-018-25066-8},
  title={Appetitive and reactive aggression are differentially associated with the STin2 genetic variant in the serotonin transporter gene},
  number={1},
  volume={8},
  journal={Scientific Reports},
  author={Hemmings, Sian Megan Joanna and Xulu, Khethelo and Sommer, Jessica and Hinsberger, Martina and Malan-Müller, Stefanie and Tromp, Gerard and Elbert, Thomas and Weierstall, Roland and Seedat, Soraya},
  note={Article Number: 6714}
}
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