Systems Toxicology : The Future of Risk Assessment

Sauer, John Michael; Hartung, Thomas; Leist, Marcel; Knudsen, Thomas B; Hoeng, Julia; Hayes, A. Wallace

Systems Toxicology : The Future of Risk Assessment

Files

Sauer_0-291326.pdf(90.85 KB)

Date

2015

Authors

Sauer, John Michael

Hartung, Thomas

Leist, Marcel

Knudsen, Thomas B

Hoeng, Julia

Hayes, A. Wallace

Publication type

Journal article

Published in

International Journal of Toxicology ; 34 (2015), 4. - pp. 346-348. - ISSN 0730-0913. - eISSN 1092-874X

Abstract

Risk assessment, in the context of public health, is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. With increasing public health concern regarding the potential risks associated with chemical exposure, there is a need for more predictive and accurate approaches to risk assessment. Developing such an approach requires a mechanistic understanding of the process by which xenobiotic substances perturb biological systems and lead to toxicity. Supplementing the shortfalls of traditional risk assessment with mechanistic biological data has been widely discussed but not routinely implemented in the evaluation of chemical exposure. These mechanistic approaches to risk assessment have been generally referred to as systems toxicology. This Symposium Overview article summarizes 4 talks presented at the 35th Annual Meeting of the American College of Toxicology.

Subject (DDC)

570 Biosciences, Biology

Cite This

ISO 690

SAUER, John Michael, Thomas HARTUNG, Marcel LEIST, Thomas B KNUDSEN, Julia HOENG, A. Wallace HAYES, 2015. Systems Toxicology : The Future of Risk Assessment. In: International Journal of Toxicology. 34(4), pp. 346-348. ISSN 0730-0913. eISSN 1092-874X. Available under: doi: 10.1177/1091581815576551

BibTex

@article{Sauer2015-07Syste-31068,
  year={2015},
  doi={10.1177/1091581815576551},
  title={Systems Toxicology : The Future of Risk Assessment},
  number={4},
  volume={34},
  issn={0730-0913},
  journal={International Journal of Toxicology},
  pages={346--348},
  author={Sauer, John Michael and Hartung, Thomas and Leist, Marcel and Knudsen, Thomas B and Hoeng, Julia and Hayes, A. Wallace}
}

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Bibliography of Konstanz

Yes