Systems Toxicology : The Future of Risk Assessment

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2015
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Sauer, John Michael
Knudsen, Thomas B
Hoeng, Julia
Hayes, A. Wallace
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Risk assessment, in the context of public health, is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. With increasing public health concern regarding the potential risks associated with chemical exposure, there is a need for more predictive and accurate approaches to risk assessment. Developing such an approach requires a mechanistic understanding of the process by which xenobiotic substances perturb biological systems and lead to toxicity. Supplementing the shortfalls of traditional risk assessment with mechanistic biological data has been widely discussed but not routinely implemented in the evaluation of chemical exposure. These mechanistic approaches to risk assessment have been generally referred to as systems toxicology. This Symposium Overview article summarizes 4 talks presented at the 35th Annual Meeting of the American College of Toxicology.

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570 Biowissenschaften, Biologie
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ISO 690SAUER, John Michael, Thomas HARTUNG, Marcel LEIST, Thomas B KNUDSEN, Julia HOENG, A. Wallace HAYES, 2015. Systems Toxicology : The Future of Risk Assessment. In: International Journal of Toxicology. 2015, 34(4), pp. 346-348. ISSN 0730-0913. eISSN 1092-874X. Available under: doi: 10.1177/1091581815576551
BibTex
@article{Sauer2015-07Syste-31068,
  year={2015},
  doi={10.1177/1091581815576551},
  title={Systems Toxicology : The Future of Risk Assessment},
  number={4},
  volume={34},
  issn={0730-0913},
  journal={International Journal of Toxicology},
  pages={346--348},
  author={Sauer, John Michael and Hartung, Thomas and Leist, Marcel and Knudsen, Thomas B and Hoeng, Julia and Hayes, A. Wallace}
}
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