Free water elimination improves test-retest reproducibility of diffusion tensor imaging indices in the brain : A longitudinal multisite study of healthy elderly subjects

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2017
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Pasternak, Ofer
Minati, Ludovico
Marizzoni, Moira
Bartrés-Faz, David
Bargalló, Núria
Bosch, Beatriz
Rossini, Paolo Maria
Marra, Camillo
Müller, Bernhard
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Free water elimination (FWE) in brain diffusion MRI has been shown to improve tissue specificity in human white matter characterization both in health and in disease. Relative to the classical diffusion tensor imaging (DTI) model, FWE is also expected to increase sensitivity to microstructural changes in longitudinal studies. However, it is not clear if these two models differ in their test-retest reproducibility. This study compares a bi-tensor model for FWE with DTI by extending a previous longitudinal-reproducibility 3T multisite study (10 sites, 7 different scanner models) of 50 healthy elderly participants (55-80 years old) scanned in two sessions at least 1 week apart. We computed the reproducibility of commonly used DTI metrics (FA: fractional anisotropy, MD: mean diffusivity, RD: radial diffusivity, and AXD: axial diffusivity), derived either using a DTI model or a FWE model. The DTI metrics were evaluated over 48 white-matter regions of the JHU-ICBM-DTI-81 white-matter labels atlas, and reproducibility errors were assessed. We found that relative to the DTI model, FWE significantly reduced reproducibility errors in most areas tested. In particular, for the FA and MD metrics, there was an average reduction of approximately 1% in the reproducibility error. The reproducibility scores did not significantly differ across sites. This study shows that FWE improves sensitivity and is thus promising for clinical applications, with the potential to identify more subtle changes. The increased reproducibility allows for smaller sample size or shorter trials in studies evaluating biomarkers of disease progression or treatment effects.

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570 Biowissenschaften, Biologie
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multisite diffusion MRI, free‐water imaging, test–retest reproducibility, brain diffusion tensor imaging, longitudinal, healthy elderly
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ISO 690ALBI, Angela, Ofer PASTERNAK, Ludovico MINATI, Moira MARIZZONI, David BARTRÉS-FAZ, Núria BARGALLÓ, Beatriz BOSCH, Paolo Maria ROSSINI, Camillo MARRA, Bernhard MÜLLER, 2017. Free water elimination improves test-retest reproducibility of diffusion tensor imaging indices in the brain : A longitudinal multisite study of healthy elderly subjects. In: Human Brain Mapping. Wiley. 2017, 38(1), pp. 12-26. ISSN 1065-9471. eISSN 1097-0193. Available under: doi: 10.1002/hbm.23350
BibTex
@article{Albi2017water-50142,
  year={2017},
  doi={10.1002/hbm.23350},
  title={Free water elimination improves test-retest reproducibility of diffusion tensor imaging indices in the brain : A longitudinal multisite study of healthy elderly subjects},
  number={1},
  volume={38},
  issn={1065-9471},
  journal={Human Brain Mapping},
  pages={12--26},
  author={Albi, Angela and Pasternak, Ofer and Minati, Ludovico and Marizzoni, Moira and Bartrés-Faz, David and Bargalló, Núria and Bosch, Beatriz and Rossini, Paolo Maria and Marra, Camillo and Müller, Bernhard}
}
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