Publikation: Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase
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Chemical Communications : ChemComm. 2017, 53(94), pp. 12704-12707. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/c7cc07173f
Zusammenfassung
The possibility to sequence cytotoxic O6-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the structural basis for this reaction which may spur future developments in DNA damage sequencing.
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BETZ, Karin, Arman NILFOROUSHAN, Laura A. WYSS, Kay DIEDERICHS, Shana J. STURLA, Andreas MARX, 2017. Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase. In: Chemical Communications : ChemComm. 2017, 53(94), pp. 12704-12707. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/c7cc07173fBibTex
@article{Betz2017-11-23Struc-40878,
year={2017},
doi={10.1039/c7cc07173f},
title={Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase},
number={94},
volume={53},
issn={1359-7345},
journal={Chemical Communications : ChemComm},
pages={12704--12707},
author={Betz, Karin and Nilforoushan, Arman and Wyss, Laura A. and Diederichs, Kay and Sturla, Shana J. and Marx, Andreas}
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<dcterms:abstract xml:lang="eng">The possibility to sequence cytotoxic O<sup>6</sup>-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the structural basis for this reaction which may spur future developments in DNA damage sequencing.</dcterms:abstract>
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