Publikation: Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase
Lade...
Dateien
Datum
2017
Autor:innen
Herausgeber:innen
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
Internationale Patentnummer
Link zur Lizenz
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Core Facility der Universität Konstanz
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Chemical Communications : ChemComm. 2017, 53(94), pp. 12704-12707. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/c7cc07173f
Zusammenfassung
The possibility to sequence cytotoxic O6-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the structural basis for this reaction which may spur future developments in DNA damage sequencing.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
540 Chemie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690
BETZ, Karin, Arman NILFOROUSHAN, Laura A. WYSS, Kay DIEDERICHS, Shana J. STURLA, Andreas MARX, 2017. Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase. In: Chemical Communications : ChemComm. 2017, 53(94), pp. 12704-12707. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/c7cc07173fBibTex
@article{Betz2017-11-23Struc-40878, year={2017}, doi={10.1039/c7cc07173f}, title={Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase}, number={94}, volume={53}, issn={1359-7345}, journal={Chemical Communications : ChemComm}, pages={12704--12707}, author={Betz, Karin and Nilforoushan, Arman and Wyss, Laura A. and Diederichs, Kay and Sturla, Shana J. and Marx, Andreas} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/40878"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-12-08T13:20:12Z</dc:date> <dc:contributor>Marx, Andreas</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dc:contributor>Sturla, Shana J.</dc:contributor> <dc:creator>Marx, Andreas</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:contributor>Betz, Karin</dc:contributor> <dc:creator>Sturla, Shana J.</dc:creator> <dc:creator>Wyss, Laura A.</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/40878/1/Betz_2-emplm7zacqca1.pdf"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/> <dc:contributor>Wyss, Laura A.</dc:contributor> <dcterms:abstract xml:lang="eng">The possibility to sequence cytotoxic O<sup>6</sup>-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the structural basis for this reaction which may spur future developments in DNA damage sequencing.</dcterms:abstract> <dc:creator>Betz, Karin</dc:creator> <dc:contributor>Diederichs, Kay</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/40878"/> <dc:language>eng</dc:language> <dcterms:title>Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase</dcterms:title> <dc:rights>terms-of-use</dc:rights> <dc:creator>Diederichs, Kay</dc:creator> <dcterms:issued>2017-11-23</dcterms:issued> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/40878/1/Betz_2-emplm7zacqca1.pdf"/> <dc:creator>Nilforoushan, Arman</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-12-08T13:20:12Z</dcterms:available> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/> <dc:contributor>Nilforoushan, Arman</dc:contributor> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> </rdf:Description> </rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja