Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase
Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase
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2017
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Chemical Communications : ChemComm ; 53 (2017), 94. - pp. 12704-12707. - ISSN 1359-7345. - eISSN 1364-548X
Abstract
The possibility to sequence cytotoxic O6-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the structural basis for this reaction which may spur future developments in DNA damage sequencing.
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BETZ, Karin, Arman NILFOROUSHAN, Laura A. WYSS, Kay DIEDERICHS, Shana J. STURLA, Andreas MARX, 2017. Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase. In: Chemical Communications : ChemComm. 53(94), pp. 12704-12707. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/c7cc07173fBibTex
@article{Betz2017-11-23Struc-40878, year={2017}, doi={10.1039/c7cc07173f}, title={Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase}, number={94}, volume={53}, issn={1359-7345}, journal={Chemical Communications : ChemComm}, pages={12704--12707}, author={Betz, Karin and Nilforoushan, Arman and Wyss, Laura A. and Diederichs, Kay and Sturla, Shana J. and Marx, Andreas} }
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