Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase

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2017
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Nilforoushan, Arman
Wyss, Laura A.
Sturla, Shana J.
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The possibility to sequence cytotoxic O6-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the structural basis for this reaction which may spur future developments in DNA damage sequencing.

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ISO 690BETZ, Karin, Arman NILFOROUSHAN, Laura A. WYSS, Kay DIEDERICHS, Shana J. STURLA, Andreas MARX, 2017. Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase. In: Chemical Communications : ChemComm. 2017, 53(94), pp. 12704-12707. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/c7cc07173f
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@article{Betz2017-11-23Struc-40878,
  year={2017},
  doi={10.1039/c7cc07173f},
  title={Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase},
  number={94},
  volume={53},
  issn={1359-7345},
  journal={Chemical Communications : ChemComm},
  pages={12704--12707},
  author={Betz, Karin and Nilforoushan, Arman and Wyss, Laura A. and Diederichs, Kay and Sturla, Shana J. and Marx, Andreas}
}
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