Endogenous MCP-1 promotes lung inflammation induced by LPS and LTA

Lade...
Vorschaubild
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
2011
Autor:innen
van Zoelen, Marieke A. D.
Verstege, Marleen I.
Draing, Christian
de Beer, Regina
van't Veer, Cornelis
Florquin, Sandrine
Bresser, Paul
Van der Zee, Jaring S.
te Velde, Anje A.
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Zusammenfassung

Monocyte chemoattractant protein 1 (MCP-1) plays an important role in leukocyte recruitment to sites of infection and inflammation. In addition, MCP-1 may attenuate inflammation by virtue of its capacity to inhibit the production of proinflammatory cytokines. We here investigated the role of MCP-1 in lung inflammation induced by lipopolysaccharide (LPS) or lipoteichoic acid (LTA), constituents of the gram-negative and gram-positive bacterial cell wall, respectively. Healthy humans demonstrated elevated MCP-1 concentrations in their bronchoalveolar lavage fluid (BALF) 6 h after inhalation of LPS. Similarly, intranasal administration of LPS or LTA to mice resulted in a rise in BALF MCP-1 levels. Murine alveolar macrophage-like cells released significant amounts of MCP-1 upon stimulation with LPS or LTA in vitro. Compared to Wt mice, MCP-1−/− mice demonstrated lower TNF-α levels and a diminished neutrophil influx into their bronchoalveolar space after either LPS or LTA instillation. After intrapulmonary delivery of LPS MCP-1−/− mice had decreased interleukin-6 and KC concentrations and less severe lung inflammation upon histopathological examination. Remarkably, MCP-1 deficiency was associated with an early enhancement of interleukin-10 release in BALF after both LPS and LTA instillation. These data suggest that MCP-1 is a proinflammatory mediator during pulmonary inflammation induced by either LPS or LTA.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Lung inflammation; Lipopolysaccharide; Lipoteichoic acid; Monocyte chemoattractant protein 1; Soluble receptor for advanced glycation end products; Animal models
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690VAN ZOELEN, Marieke A. D., Marleen I. VERSTEGE, Christian DRAING, Regina DE BEER, Cornelis VAN'T VEER, Sandrine FLORQUIN, Paul BRESSER, Jaring S. VAN DER ZEE, Anje A. TE VELDE, Sonja von AULOCK, Tom VAN DER POLL, 2011. Endogenous MCP-1 promotes lung inflammation induced by LPS and LTA. In: Molecular Immunology. Elsevier. 2011, 48(12-13), pp. 1468-1476. ISSN 0161-5890. eISSN 1872-9142. Available under: doi: 10.1016/j.molimm.2011.04.001
BibTex
@article{vanZoelen2011-07Endog-51216,
  year={2011},
  doi={10.1016/j.molimm.2011.04.001},
  title={Endogenous MCP-1 promotes lung inflammation induced by LPS and LTA},
  number={12-13},
  volume={48},
  issn={0161-5890},
  journal={Molecular Immunology},
  pages={1468--1476},
  author={van Zoelen, Marieke A. D. and Verstege, Marleen I. and Draing, Christian and de Beer, Regina and van't Veer, Cornelis and Florquin, Sandrine and Bresser, Paul and Van der Zee, Jaring S. and te Velde, Anje A. and Aulock, Sonja von and van der Poll, Tom}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/51216">
    <dc:creator>Verstege, Marleen I.</dc:creator>
    <dcterms:abstract xml:lang="eng">Monocyte chemoattractant protein 1 (MCP-1) plays an important role in leukocyte recruitment to sites of infection and inflammation. In addition, MCP-1 may attenuate inflammation by virtue of its capacity to inhibit the production of proinflammatory cytokines. We here investigated the role of MCP-1 in lung inflammation induced by lipopolysaccharide (LPS) or lipoteichoic acid (LTA), constituents of the gram-negative and gram-positive bacterial cell wall, respectively. Healthy humans demonstrated elevated MCP-1 concentrations in their bronchoalveolar lavage fluid (BALF) 6 h after inhalation of LPS. Similarly, intranasal administration of LPS or LTA to mice resulted in a rise in BALF MCP-1 levels. Murine alveolar macrophage-like cells released significant amounts of MCP-1 upon stimulation with LPS or LTA in vitro. Compared to Wt mice, MCP-1&lt;sup&gt;−/−&lt;/sup&gt; mice demonstrated lower TNF-α levels and a diminished neutrophil influx into their bronchoalveolar space after either LPS or LTA instillation. After intrapulmonary delivery of LPS MCP-1&lt;sup&gt;−/−&lt;/sup&gt; mice had decreased interleukin-6 and KC concentrations and less severe lung inflammation upon histopathological examination. Remarkably, MCP-1 deficiency was associated with an early enhancement of interleukin-10 release in BALF after both LPS and LTA instillation. These data suggest that MCP-1 is a proinflammatory mediator during pulmonary inflammation induced by either LPS or LTA.</dcterms:abstract>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>van Zoelen, Marieke A. D.</dc:contributor>
    <dc:contributor>de Beer, Regina</dc:contributor>
    <dc:contributor>van't Veer, Cornelis</dc:contributor>
    <dc:contributor>Florquin, Sandrine</dc:contributor>
    <dc:creator>Aulock, Sonja von</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>te Velde, Anje A.</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Van der Zee, Jaring S.</dc:creator>
    <dc:creator>van Zoelen, Marieke A. D.</dc:creator>
    <dc:creator>Florquin, Sandrine</dc:creator>
    <dc:contributor>van der Poll, Tom</dc:contributor>
    <dc:contributor>Van der Zee, Jaring S.</dc:contributor>
    <dc:contributor>Verstege, Marleen I.</dc:contributor>
    <dcterms:issued>2011-07</dcterms:issued>
    <dc:creator>van der Poll, Tom</dc:creator>
    <dc:creator>van't Veer, Cornelis</dc:creator>
    <dc:creator>de Beer, Regina</dc:creator>
    <dc:language>eng</dc:language>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Draing, Christian</dc:creator>
    <dc:contributor>Bresser, Paul</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-10-06T09:00:53Z</dcterms:available>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/51216"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-10-06T09:00:53Z</dc:date>
    <dc:contributor>Draing, Christian</dc:contributor>
    <dc:contributor>Aulock, Sonja von</dc:contributor>
    <dcterms:title>Endogenous MCP-1 promotes lung inflammation induced by LPS and LTA</dcterms:title>
    <dc:creator>te Velde, Anje A.</dc:creator>
    <dc:creator>Bresser, Paul</dc:creator>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja
Diese Publikation teilen