Publikation:

Lymph Node T Cell Homeostasis Relies on Steady State Homing of Dendritic Cells

Vorschaubild

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2011

Autor:innen

Wendland, Meike
Willenzon, Stefanie
Kocks, Jessica
Davalos-Misslitz, Ana Clara
Hammerschmidt, Swantje I.
Kremmer, Elisabeth
Sixt, Michael
Hoffmeyer, Angelika
Förster, Reinhold
et al.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.immuni.2011.10.017
ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Deutsche Forschungsgemeinschaft (DFG): SFB621-A1
Deutsche Forschungsgemeinschaft (DFG): SFB587-B3

Projekt

Open Access-Veröffentlichung

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Immunity. Elsevier. 2011, 35(6), S. 945-957. ISSN 1074-7613. eISSN 1097-4180. Verfügbar unter: doi: 10.1016/j.immuni.2011.10.017

Zusammenfassung

Little is known about mechanisms determining the homeostasis of lymphocytes within lymphoid organs. Applying different mouse models, including conditionally proficient Ccr7 gene-targeted mice, we now show that semimature steady state dendritic cells (sDCs) constitutively trafficking into lymph nodes (LNs) were essential contributors to T cell homeostasis in these organs. sDCs provided vascular endothelial growth factor known to support high endothelial venule formation, thus facilitating enhanced homing of T cells to LNs. The presence of sDCs led to increased CCL21 production in T-zone fibroblastic reticular cells. CCL21 is a ligand for CCR7 known to regulate homing as well as retention of T cells in LNs. In addition, we provide evidence that CCL21 binds to the surface of DCs via its heparin-binding domain, further explaining why T cells leave LNs more rapidly in the absence of sDCs. Together, these data reveal multiple roles for sDCs in regulating T cell homeostasis in LNs.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690WENDLAND, Meike, Stefanie WILLENZON, Jessica KOCKS, Ana Clara DAVALOS-MISSLITZ, Swantje I. HAMMERSCHMIDT, Kathrin SCHUMANN, Elisabeth KREMMER, Michael SIXT, Angelika HOFFMEYER, Reinhold FÖRSTER, 2011. Lymph Node T Cell Homeostasis Relies on Steady State Homing of Dendritic Cells. In: Immunity. Elsevier. 2011, 35(6), S. 945-957. ISSN 1074-7613. eISSN 1097-4180. Verfügbar unter: doi: 10.1016/j.immuni.2011.10.017
BibTex
@article{Wendland2011-12Lymph-73160,
  title={Lymph Node T Cell Homeostasis Relies on Steady State Homing of Dendritic Cells},
  year={2011},
  doi={10.1016/j.immuni.2011.10.017},
  number={6},
  volume={35},
  issn={1074-7613},
  journal={Immunity},
  pages={945--957},
  author={Wendland, Meike and Willenzon, Stefanie and Kocks, Jessica and Davalos-Misslitz, Ana Clara and Hammerschmidt, Swantje I. and Schumann, Kathrin and Kremmer, Elisabeth and Sixt, Michael and Hoffmeyer, Angelika and Förster, Reinhold}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/73160">
    <dc:creator>Hoffmeyer, Angelika</dc:creator>
    <dc:creator>Davalos-Misslitz, Ana Clara</dc:creator>
    <dc:contributor>Schumann, Kathrin</dc:contributor>
    <dcterms:issued>2011-12</dcterms:issued>
    <dc:creator>Kremmer, Elisabeth</dc:creator>
    <dc:contributor>Hammerschmidt, Swantje I.</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2025-04-29T11:27:14Z</dcterms:available>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2025-04-29T11:27:14Z</dc:date>
    <dc:contributor>Wendland, Meike</dc:contributor>
    <dc:creator>Wendland, Meike</dc:creator>
    <dc:creator>Kocks, Jessica</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Davalos-Misslitz, Ana Clara</dc:contributor>
    <dc:creator>Schumann, Kathrin</dc:creator>
    <dc:creator>Willenzon, Stefanie</dc:creator>
    <dc:creator>Sixt, Michael</dc:creator>
    <dc:creator>Hammerschmidt, Swantje I.</dc:creator>
    <dc:language>eng</dc:language>
    <dc:contributor>Willenzon, Stefanie</dc:contributor>
    <dc:contributor>Förster, Reinhold</dc:contributor>
    <dcterms:abstract>Little is known about mechanisms determining the homeostasis of lymphocytes within lymphoid organs. Applying different mouse models, including conditionally proficient Ccr7 gene-targeted mice, we now show that semimature steady state dendritic cells (sDCs) constitutively trafficking into lymph nodes (LNs) were essential contributors to T cell homeostasis in these organs. sDCs provided vascular endothelial growth factor known to support high endothelial venule formation, thus facilitating enhanced homing of T cells to LNs. The presence of sDCs led to increased CCL21 production in T-zone fibroblastic reticular cells. CCL21 is a ligand for CCR7 known to regulate homing as well as retention of T cells in LNs. In addition, we provide evidence that CCL21 binds to the surface of DCs via its heparin-binding domain, further explaining why T cells leave LNs more rapidly in the absence of sDCs. Together, these data reveal multiple roles for sDCs in regulating T cell homeostasis in LNs.</dcterms:abstract>
    <dc:contributor>Sixt, Michael</dc:contributor>
    <dc:contributor>Hoffmeyer, Angelika</dc:contributor>
    <dc:contributor>Kocks, Jessica</dc:contributor>
    <dc:creator>Förster, Reinhold</dc:creator>
    <dcterms:title>Lymph Node T Cell Homeostasis Relies on Steady State Homing of Dendritic Cells</dcterms:title>
    <dc:contributor>Kremmer, Elisabeth</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/73160"/>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Ja
Diese Publikation teilen