Good cell culture practices & in vitro toxicology

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2017
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Eskes, Chantra
Boström, Ann-Charlotte
Bowe, Gerhard
Coecke, Sandra
Hendriks, Giel
Pamies, David
Piton, Alain
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Toxicology in Vitro. 2017, 45(Pt 3), pp. 272-277. ISSN 0887-2333. eISSN 1879-3177. Available under: doi: 10.1016/j.tiv.2017.04.022
Zusammenfassung

Good Cell Culture Practices (GCCP) is of high relevance to in vitro toxicology. The European Society of Toxicology In Vitro (ESTIV), the Center for Alternatives for Animal Testing (CAAT) and the In Vitro Toxicology Industrial Platform (IVTIP) joined forces to address by means of an ESTIV 2016 pre-congress session the different aspects and applications of GCCP. The covered aspects comprised the current status of the OECD guidance document on Good In Vitro Method Practices, the importance of quality assurance for new technological advances in in vitro toxicology including stem cells, and the optimized implementation of Good Manufacturing Practices and Good Laboratory Practices for regulatory testing purposes. General discussions raised the duality related to the difficulties in implementing GCCP in an academic innovative research framework on one hand, and on the other hand, the need for such GCCP principles in order to ensure reproducibility and robustness of in vitro test methods for toxicity testing. Indeed, if good cell culture principles are critical to take into consideration for all uses of in vitro test methods for toxicity testing, the level of application of such principles may depend on the stage of development of the test method as well as on the applications of the test methods, i.e., academic innovative research vs. regulatory standardized test method.

Zusammenfassung in einer weiteren Sprache
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570 Biowissenschaften, Biologie
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ISO 690ESKES, Chantra, Ann-Charlotte BOSTRÖM, Gerhard BOWE, Sandra COECKE, Thomas HARTUNG, Giel HENDRIKS, David PAMIES, Alain PITON, Costanza ROVIDA, 2017. Good cell culture practices & in vitro toxicology. In: Toxicology in Vitro. 2017, 45(Pt 3), pp. 272-277. ISSN 0887-2333. eISSN 1879-3177. Available under: doi: 10.1016/j.tiv.2017.04.022
BibTex
@article{Eskes2017-12cultu-41328,
  year={2017},
  doi={10.1016/j.tiv.2017.04.022},
  title={Good cell culture practices & in vitro toxicology},
  number={Pt 3},
  volume={45},
  issn={0887-2333},
  journal={Toxicology in Vitro},
  pages={272--277},
  author={Eskes, Chantra and Boström, Ann-Charlotte and Bowe, Gerhard and Coecke, Sandra and Hartung, Thomas and Hendriks, Giel and Pamies, David and Piton, Alain and Rovida, Costanza}
}
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