Publikation:

Spheroids formation in large drops suspended in superhydrophobic paper cones

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2024

Autor:innen

Mohapatra, Omkar
Ashraf, Rahail
Easo George, Jijo
Patil, Saniya
Mukherjee, Raju
Mampallil, Dileep

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Core Facility der Universität Konstanz

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Published

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Biomicrofluidics. AIP Publishing. 2024, 18(2), 024107. eISSN 1932-1058. Verfügbar unter: doi: 10.1063/5.0197807

Zusammenfassung

The utilization of 3D cell culture for spheroid formation holds significant implications in cancer research, contributing to a fundamental understanding of the disease and aiding drug development. Conventional methods such as the hanging drop technique and other alternatives encounter limitations due to smaller drop volumes, leading to nutrient starvation and restricted culture duration. In this study, we present a straightforward approach to creating superhydrophobic paper cones capable of accommodating large volumes of culture media drops. These paper cones have sterility, autoclavability, and bacterial repellent properties. Leveraging these attributes, we successfully generate large spheroids of ovarian cancer cells and, as a proof of concept, conduct drug screening to assess the impact of carboplatin. Thus, our method enables the preparation of flexible superhydrophobic surfaces for laboratory applications in an expeditious manner, exemplified here through spheroid formation and drug screening demonstrations.

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Fachgebiet (DDC)
530 Physik

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Ultrahydrophobicity, Fluid drops, Bacterial adhesion, Carboplatin, Cell cultures

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ISO 690MOHAPATRA, Omkar, Maheshwar Reddy GOPU, Rahail ASHRAF, Jijo EASO GEORGE, Saniya PATIL, Raju MUKHERJEE, Sanjay VINOD KUMAR, Dileep MAMPALLIL, 2024. Spheroids formation in large drops suspended in superhydrophobic paper cones. In: Biomicrofluidics. AIP Publishing. 2024, 18(2), 024107. eISSN 1932-1058. Verfügbar unter: doi: 10.1063/5.0197807
BibTex
@article{Mohapatra2024-03-01Spher-71799,
  year={2024},
  doi={10.1063/5.0197807},
  title={Spheroids formation in large drops suspended in superhydrophobic paper cones},
  number={2},
  volume={18},
  journal={Biomicrofluidics},
  author={Mohapatra, Omkar and Gopu, Maheshwar Reddy and Ashraf, Rahail and Easo George, Jijo and Patil, Saniya and Mukherjee, Raju and Vinod Kumar, Sanjay and Mampallil, Dileep},
  note={Article Number: 024107}
}
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