Publikation:

TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses

Vorschaubild

Dateien

Schlosser_opus-85078.pdf
Schlosser_opus-85078.pdfGröße: 652.1 KBDownloads: 694

Datum

2008

Autor:innen

Schlosser, Eva Christine
Fischer, Stefan
Basta, Sameh
Busch, Dirk H.
Gander, Bruno

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-85078
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.vaccine.2008.01.030
ArXiv-ID

Internationale Patentnummer

Link zur Lizenz
Urheberrechtlich geschützt

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Green

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Vaccine. 2008, 26(13), pp. 1626-1637. ISSN 0264-410X. Available under: doi: 10.1016/j.vaccine.2008.01.030

Zusammenfassung

Dendritic cells phagocytose pathogens leading to maturation and cross-presentation on MHC class I. We found that the efficiency of cross-priming in mice after vaccination with biodegradable poly(D,L-lactide-co-glycolide) microspheres (MSs) was enhanced when ovalbumin was coencapsulated together with either a CpG oligonucleotide or polyI:C as compared to co-inoculation of ovalbumin-bearing MS with soluble or separately encapsulated adjuvants. A single immunization with MS containing coencaspsulated CpG and ovalbumin yielded 9% SIINFEKL/H-2K(b) tetramer positive CTLs, production of IFN-gamma, efficient cytolysis, and protection from vaccinia virus infection. Taken together, coencapsulation of adjuvant and antigen is an important paradigm for the generation of potent CTL responses.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Verknüpfte Datensätze

Zitieren

ISO 690SCHLOSSER, Eva Christine, Marc MÜLLER, Stefan FISCHER, Sameh BASTA, Dirk H. BUSCH, Bruno GANDER, Marcus GRÖTTRUP, 2008. TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses. In: Vaccine. 2008, 26(13), pp. 1626-1637. ISSN 0264-410X. Available under: doi: 10.1016/j.vaccine.2008.01.030
BibTex
@article{Schlosser2008ligan-1194,
  year={2008},
  doi={10.1016/j.vaccine.2008.01.030},
  title={TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses},
  number={13},
  volume={26},
  issn={0264-410X},
  journal={Vaccine},
  pages={1626--1637},
  author={Schlosser, Eva Christine and Müller, Marc and Fischer, Stefan and Basta, Sameh and Busch, Dirk H. and Gander, Bruno and Gröttrup, Marcus}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/1194">
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:creator>Fischer, Stefan</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:45Z</dcterms:available>
    <dc:creator>Gander, Bruno</dc:creator>
    <dc:creator>Schlosser, Eva Christine</dc:creator>
    <dcterms:bibliographicCitation>Publ. in: Vaccine 26 (2008), 13, pp. 1626-1637</dcterms:bibliographicCitation>
    <dc:contributor>Gander, Bruno</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:rights>terms-of-use</dc:rights>
    <dc:creator>Busch, Dirk H.</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-23T09:06:45Z</dc:date>
    <dcterms:issued>2008</dcterms:issued>
    <dc:creator>Gröttrup, Marcus</dc:creator>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/1194/1/Schlosser_opus-85078.pdf"/>
    <dc:contributor>Gröttrup, Marcus</dc:contributor>
    <dc:creator>Basta, Sameh</dc:creator>
    <dc:contributor>Schlosser, Eva Christine</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Müller, Marc</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/1194/1/Schlosser_opus-85078.pdf"/>
    <dc:contributor>Basta, Sameh</dc:contributor>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/1194"/>
    <dcterms:title>TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses</dcterms:title>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Müller, Marc</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:contributor>Busch, Dirk H.</dc:contributor>
    <dcterms:abstract>Dendritic cells phagocytose pathogens leading to maturation and cross-presentation on MHC class I. We found that the efficiency of cross-priming in mice after vaccination with biodegradable poly(D,L-lactide-co-glycolide) microspheres (MSs) was enhanced when ovalbumin was coencapsulated together with either a CpG oligonucleotide or polyI:C as compared to co-inoculation of ovalbumin-bearing MS with soluble or separately encapsulated adjuvants. A single immunization with MS containing coencaspsulated CpG and ovalbumin yielded 9% SIINFEKL/H-2K(b) tetramer positive CTLs, production of IFN-gamma, efficient cytolysis, and protection from vaccinia virus infection. Taken together, coencapsulation of adjuvant and antigen is an important paradigm for the generation of potent CTL responses.</dcterms:abstract>
    <dc:contributor>Fischer, Stefan</dc:contributor>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen