Induction of ketosis in rats fed low-carbohydrate, high fat diets depends on the relative abundance of dietary fat and protein

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2011
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Bielohuby, Maximilian
Menhofer, Dominik
Kirchner, Henriette
Stoehr, Barbara J. M.
Müller, Timo D.
Stock, Peggy
Hempel, Madlen
Pfluger, Paul T.
Kienzle, Ellen
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American journal of physiology: endocrinology and metabolism. 2011, 300(1), pp. E65-E76. ISSN 0193-1849. eISSN 1522-1555. Available under: doi: 10.1152/ajpendo.00478.2010
Zusammenfassung

Low-carbohydrate/high-fat diets (LC-HFDs) in rodent models have been implicated with both weight loss and as therapeutic approach to treat neurological diseases. LC-HFDs are known to induce ketosis, however, systematic studies analyzing the impact of the macronutrient composition on ketosis induction and weight loss success are lacking. Methods: Male Wistar rats were pair-fed either a standard chow diet or one of 3 different LC-HFDs for 4 weeks, which only differed in the relative abundance of fat and protein (percentages of fat/protein in dry matter: LC-75/10; LC-65/20; LC-55/30). We subsequently measured body composition by NMR, analyzed blood chemistry and urine acetone content, evaluated gene expression changes of key ketogenic and gluconeogenic genes, and measured energy expenditure (EE) and locomotor activity (LA) during the first 4 days and after 3 weeks on the respective diets. Results: Compared to chow, rats fed with LC-75/10, LC-65/20 and LC-55/30 gained significantly less bodyweight. Reductions in body weight were mainly due to lower lean body mass and paralleled by significantly increased fat mass. Levels of β-hydroxybutyate were significantly elevated feeding LC-75/10 and LC-65/20 but decreased in parallel to reductions in dietary fat. Acetone was about 16-fold higher with LC-75/10, only (p

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570 Biowissenschaften, Biologie
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Atkins'-style diets, ketone bodies, gluconeogenesis, energy expenditure, weight loss
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ISO 690BIELOHUBY, Maximilian, Dominik MENHOFER, Henriette KIRCHNER, Barbara J. M. STOEHR, Timo D. MÜLLER, Peggy STOCK, Madlen HEMPEL, Kerstin STEMMER, Paul T. PFLUGER, Ellen KIENZLE, Bruno CHRIST, Matthias H. TSCHÖP, Martin BIDLINGMAIER, 2011. Induction of ketosis in rats fed low-carbohydrate, high fat diets depends on the relative abundance of dietary fat and protein. In: American journal of physiology: endocrinology and metabolism. 2011, 300(1), pp. E65-E76. ISSN 0193-1849. eISSN 1522-1555. Available under: doi: 10.1152/ajpendo.00478.2010
BibTex
@article{Bielohuby2011Induc-319,
  year={2011},
  doi={10.1152/ajpendo.00478.2010},
  title={Induction of ketosis in rats fed low-carbohydrate, high fat diets depends on the relative abundance of dietary fat and protein},
  number={1},
  volume={300},
  issn={0193-1849},
  journal={American journal of physiology: endocrinology and metabolism},
  pages={E65--E76},
  author={Bielohuby, Maximilian and Menhofer, Dominik and Kirchner, Henriette and Stoehr, Barbara J. M. and Müller, Timo D. and Stock, Peggy and Hempel, Madlen and Stemmer, Kerstin and Pfluger, Paul T. and Kienzle, Ellen and Christ, Bruno and Tschöp, Matthias H. and Bidlingmaier, Martin}
}
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