Induction of human IgE synthesis in B cells by mast cells and basophils

Lade...
Vorschaubild
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
1993
Autor:innen
Gauchat, Jean-Francois
Henchoz, Sybille
Mazzei, Gonzalo
Aubry, Jean-Pierre
Blasey, Horst
Life, Paul
Talabot, Dominique
Flores-Romo, Leopoldo
Thompson, Jeff
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
DOI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Zusammenfassung

Immunoglobulin E (IgE) is central to the induction of allergic diseases through its binding to the high-affinity receptor (Fc epsilon R1) on mast cells and basophils. Crosslinking by allergens of the bound IgE leads to the release of various inflammatory mediators. IgE production by B cells requires a physical interaction with T cells, involving a number of surface adhesion molecules, as well as the soluble factors interleukin-4 (IL-4) and IL-13 (ref. 5) produced by T cells, basophils and mast cells. Here we report that, in the presence of IL-4, mast and basophilic cell lines can provide the cell contact signals that are required for IgE synthesis. The human cell lines HMC-1 (mast) and KU812 (basophilic) both express the ligand for CD40 (CD40L) which is shown to be responsible for the IgE production. Moreover, freshly isolated purified human lung mast cells and blood basophils are also shown to express CD40L and to induce IgE production. This evidence suggests that mast cells and basophils may therefore play a key role in allergy not only by producing inflammatory mediators, but also by directly regulating IgE production independently of T cells.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690GAUCHAT, Jean-Francois, Sybille HENCHOZ, Gonzalo MAZZEI, Jean-Pierre AUBRY, Thomas BRUNNER, Horst BLASEY, Paul LIFE, Dominique TALABOT, Leopoldo FLORES-ROMO, Jeff THOMPSON, Kenji KISHI, Joseph BUTTERFIELD, Clemens DAHINDEN, Jean-Yves BONNEFOY, 1993. Induction of human IgE synthesis in B cells by mast cells and basophils. In: Nature. 1993, 365(6444), pp. 340-343. ISSN 0028-0836. Available under: doi: 10.1038/365340a0
BibTex
@article{Gauchat1993-09-23Induc-14337,
  year={1993},
  doi={10.1038/365340a0},
  title={Induction of human IgE synthesis in B cells by mast cells and basophils},
  number={6444},
  volume={365},
  issn={0028-0836},
  journal={Nature},
  pages={340--343},
  author={Gauchat, Jean-Francois and Henchoz, Sybille and Mazzei, Gonzalo and Aubry, Jean-Pierre and Brunner, Thomas and Blasey, Horst and Life, Paul and Talabot, Dominique and Flores-Romo, Leopoldo and Thompson, Jeff and Kishi, Kenji and Butterfield, Joseph and Dahinden, Clemens and Bonnefoy, Jean-Yves}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/14337">
    <dc:creator>Brunner, Thomas</dc:creator>
    <dc:creator>Blasey, Horst</dc:creator>
    <dcterms:issued>1993-09-23</dcterms:issued>
    <dc:contributor>Talabot, Dominique</dc:contributor>
    <dc:contributor>Dahinden, Clemens</dc:contributor>
    <dc:creator>Henchoz, Sybille</dc:creator>
    <dc:creator>Dahinden, Clemens</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-25T05:49:44Z</dcterms:available>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-10-25T05:49:44Z</dc:date>
    <dcterms:bibliographicCitation>Publ. in: Nature ; 365 (1993), 6444. - pp. 340-343</dcterms:bibliographicCitation>
    <dcterms:abstract>Immunoglobulin E (IgE) is central to the induction of allergic diseases through its binding to the high-affinity receptor (Fc epsilon R1) on mast cells and basophils. Crosslinking by allergens of the bound IgE leads to the release of various inflammatory mediators. IgE production by B cells requires a physical interaction with T cells, involving a number of surface adhesion molecules, as well as the soluble factors interleukin-4 (IL-4) and IL-13 (ref. 5) produced by T cells, basophils and mast cells. Here we report that, in the presence of IL-4, mast and basophilic cell lines can provide the cell contact signals that are required for IgE synthesis. The human cell lines HMC-1 (mast) and KU812 (basophilic) both express the ligand for CD40 (CD40L) which is shown to be responsible for the IgE production. Moreover, freshly isolated purified human lung mast cells and blood basophils are also shown to express CD40L and to induce IgE production. This evidence suggests that mast cells and basophils may therefore play a key role in allergy not only by producing inflammatory mediators, but also by directly regulating IgE production independently of T cells.</dcterms:abstract>
    <dc:creator>Mazzei, Gonzalo</dc:creator>
    <dc:creator>Talabot, Dominique</dc:creator>
    <dc:creator>Thompson, Jeff</dc:creator>
    <dc:contributor>Kishi, Kenji</dc:contributor>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/14337"/>
    <dc:creator>Aubry, Jean-Pierre</dc:creator>
    <dc:contributor>Flores-Romo, Leopoldo</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Butterfield, Joseph</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Thompson, Jeff</dc:contributor>
    <dc:contributor>Mazzei, Gonzalo</dc:contributor>
    <dc:contributor>Butterfield, Joseph</dc:contributor>
    <dc:contributor>Gauchat, Jean-Francois</dc:contributor>
    <dc:contributor>Henchoz, Sybille</dc:contributor>
    <dc:creator>Flores-Romo, Leopoldo</dc:creator>
    <dc:contributor>Aubry, Jean-Pierre</dc:contributor>
    <dc:creator>Kishi, Kenji</dc:creator>
    <dc:contributor>Blasey, Horst</dc:contributor>
    <dc:contributor>Bonnefoy, Jean-Yves</dc:contributor>
    <dc:creator>Life, Paul</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:rights>terms-of-use</dc:rights>
    <dc:creator>Gauchat, Jean-Francois</dc:creator>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:creator>Bonnefoy, Jean-Yves</dc:creator>
    <dc:contributor>Life, Paul</dc:contributor>
    <dc:contributor>Brunner, Thomas</dc:contributor>
    <dc:language>eng</dc:language>
    <dcterms:title>Induction of human IgE synthesis in B cells by mast cells and basophils</dcterms:title>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen