@article{Langhorst2006-04Prefo-6738,
  year={2006},
  doi={10.1096/fj.05-4760fje},
  title={Preformed reggie/flotillin caps : stable priming platforms for macrodomain assembly in T cells},
  number={6},
  volume={20},
  issn={0892-6638},
  journal={The FASEB Journal},
  pages={711--713},
  author={Langhorst, Matthias F. and Reuter, Alexander and Luxenhofer, Georg and Boneberg, Eva-Maria and Legler, Daniel and Plattner, Helmut and Stürmer, Claudia}
}

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    <dc:language>eng</dc:language>
    <dc:creator>Langhorst, Matthias F.</dc:creator>
    <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights>
    <dcterms:issued>2006-04</dcterms:issued>
    <dc:creator>Plattner, Helmut</dc:creator>
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    <dcterms:abstract xml:lang="eng">T cell activation after contact with an antigen-presenting cell depends on the regulated assembly of the T cell receptor signaling complex, which involves the polarized assembly of a stable, raftlike macrodomain surrounding engaged T cell receptors. Here we show that the preformed reggie/flotillin caps present in resting T cells act as priming platforms for macrodomain assembly. Preformed reggie-1/flotillin-2 caps are exceptionally stable, as shown by fluorescence recovery after photobleaching (FRAP). Upon T cell stimulation, signaling molecules are recruited to the stable reggie/flotillin caps. Importantly, a trans-negative reggie-1/flotillin-2 deletion mutant, which interferes with assembly of the preformed reggie/flotillin cap, impairs raft polarization and macrodomain formation after T cell activation. Accordingly, expression of the trans-negative reggie-1 mutant leads to the incorrect positioning of the guanine nucleotide exchange factor Vav, resulting in defects in cytoskeletal reorganization. Thus, the preformed reggie/flotillin caps are stable priming platforms for the assembly of multiprotein complexes controlling actin reorganization during T cell activation.</dcterms:abstract>
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    <dcterms:title>Preformed reggie/flotillin caps : stable priming platforms for macrodomain assembly in T cells</dcterms:title>
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    <dc:contributor>Boneberg, Eva-Maria</dc:contributor>
    <dc:creator>Legler, Daniel</dc:creator>
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    <dcterms:bibliographicCitation>First publ. in: The FASEB Journal ; 20 (2006), 6. -  S. 711-713</dcterms:bibliographicCitation>
    <dc:contributor>Luxenhofer, Georg</dc:contributor>
    <dc:contributor>Stürmer, Claudia</dc:contributor>
    <dc:contributor>Legler, Daniel</dc:contributor>
    <dc:creator>Luxenhofer, Georg</dc:creator>
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    <dc:contributor>Langhorst, Matthias F.</dc:contributor>
    <dc:creator>Stürmer, Claudia</dc:creator>
    <dc:creator>Boneberg, Eva-Maria</dc:creator>
    <dc:contributor>Reuter, Alexander</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:28:50Z</dc:date>
    <dc:creator>Reuter, Alexander</dc:creator>
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    <dc:contributor>Plattner, Helmut</dc:contributor>
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