CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway

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1998
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Meyer, Thomas F.
Gulbins, Erich
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Zusammenfassung

The interaction of Neisseria gonorrhoeae with human phagocytes is a hallmark of gonococcal infections. Recently, CD66 molecules have been characterized as receptors for Opa52-expressing gonococci on human neutrophils. Here we show that Opa52-expressing gonococci or Escherichia coli or F(ab) fragments directed against CD66, respectively, activate a signalling cascade from CD66 via Src-like protein tyrosine kinases, Rac1 and PAK to Jun-N-terminal kinase. The induced signal is distinct from Fcg-receptor-mediated signalling and is specific for Opa52, since piliated Opa gonococci, commensal Neisseria cinerea or E.coli do not stimulate this signalling pathway. Inhibition of Src-like kinases or Rac1 prevents the uptake of Opa52 bacteria, demonstrating the crucial role of this signalling cascade for the opsonin-independent, Opa52/CD66-mediated phagocytosis of pathogenic Neisseria.

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570 Biowissenschaften, Biologie
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gonococci, phagocytes, Rac1, signal, transduction, Src-like kinases
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ISO 690HAUCK, Christof R., Thomas F. MEYER, Florian LANG, Erich GULBINS, 1998. CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway. In: The EMBO Journal. 1998, 17(2), pp. 443-454. ISSN 0261-4189. eISSN 1460-2075. Available under: doi: 10.1093/emboj/17.2.443
BibTex
@article{Hauck1998CD66m-7088,
  year={1998},
  doi={10.1093/emboj/17.2.443},
  title={CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway},
  number={2},
  volume={17},
  issn={0261-4189},
  journal={The EMBO Journal},
  pages={443--454},
  author={Hauck, Christof R. and Meyer, Thomas F. and Lang, Florian and Gulbins, Erich}
}
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