CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogens

Pils, Stefan; Gerrard, Dave T.; Meyer, Axel; Hauck, Christof R.

CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogens

Dateien

CEACAM3.pdfGröße: 227.7 KBDownloads: 728

Datum

2008

Autor:innen

Pils, Stefan

Gerrard, Dave T.

Meyer, Axel

Hauck, Christof R.

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

International Journal of Medical Microbiology. 2008, 298(7-8), pp. 553-560. ISSN 1438-4221. eISSN 1618-0607. Available under: doi: 10.1016/j.ijmm.2008.04.005

Zusammenfassung

Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) is an immunoglobulin-related glycoprotein exclusively expressed on granulocytes. In contrast to other members of the CEACAM family, CEACAM3 does not support cell cell adhesion, but rather mediates the opsonin-independent recognition and elimination of a restricted set of human-specific Gram-negative bacterial pathogens including Neisseria gonorrhoeae, Haemophilus influenzae, and Moraxella catarrhalis. Within the last 4 years, molecular determinants of CEACAM3 function and CEACAM3-initiated signaling pathways have been elucidated. Sequence comparison between CEACAM3 and other CEACAM family members points to a chimeric origin of this receptor with the bacteriabinding extracellular domain and the function-promoting intracellular domain derived from different genes. This review summarizes the current knowledge about the structure function relationship of CEACAM3 and tries to combine these molecular aspects with a plausible scenario concerning the evolutionary origin of this phagocyte receptor in the light of host pathogen adaptation.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

ITAM, Signal transduction, Phagocytosis, Host pathogen coevolution

Zitieren

ISO 690

PILS, Stefan, Dave T. GERRARD, Axel MEYER, Christof R. HAUCK, 2008. CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogens. In: International Journal of Medical Microbiology. 2008, 298(7-8), pp. 553-560. ISSN 1438-4221. eISSN 1618-0607. Available under: doi: 10.1016/j.ijmm.2008.04.005

BibTex

@article{Pils2008CEACA-8322,
  year={2008},
  doi={10.1016/j.ijmm.2008.04.005},
  title={CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogens},
  number={7-8},
  volume={298},
  issn={1438-4221},
  journal={International Journal of Medical Microbiology},
  pages={553--560},
  author={Pils, Stefan and Gerrard, Dave T. and Meyer, Axel and Hauck, Christof R.}
}

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    <dcterms:abstract xml:lang="eng">Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) is an immunoglobulin-related glycoprotein exclusively expressed on granulocytes. In contrast to other members of the CEACAM family, CEACAM3 does not support cell cell adhesion, but rather mediates the opsonin-independent recognition and elimination of a restricted set of human-specific Gram-negative bacterial pathogens including Neisseria gonorrhoeae, Haemophilus influenzae, and Moraxella catarrhalis. Within the last 4 years, molecular determinants of CEACAM3 function and CEACAM3-initiated signaling pathways have been elucidated. Sequence comparison between CEACAM3 and other CEACAM family members points to a chimeric origin of this receptor with the bacteriabinding extracellular domain and the function-promoting intracellular domain derived from different genes. This review summarizes the current knowledge about the structure function relationship of CEACAM3 and tries to combine these molecular aspects with a plausible scenario concerning the evolutionary origin of this phagocyte receptor in the light of host pathogen adaptation.</dcterms:abstract>
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