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CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogens

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2008

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International Journal of Medical Microbiology. 2008, 298(7-8), pp. 553-560. ISSN 1438-4221. eISSN 1618-0607. Available under: doi: 10.1016/j.ijmm.2008.04.005

Zusammenfassung

Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) is an immunoglobulin-related glycoprotein exclusively expressed on granulocytes. In contrast to other members of the CEACAM family, CEACAM3 does not support cell cell adhesion, but rather mediates the opsonin-independent recognition and elimination of a restricted set of human-specific Gram-negative bacterial pathogens including Neisseria gonorrhoeae, Haemophilus influenzae, and Moraxella catarrhalis. Within the last 4 years, molecular determinants of CEACAM3 function and CEACAM3-initiated signaling pathways have been elucidated. Sequence comparison between CEACAM3 and other CEACAM family members points to a chimeric origin of this receptor with the bacteriabinding extracellular domain and the function-promoting intracellular domain derived from different genes. This review summarizes the current knowledge about the structure function relationship of CEACAM3 and tries to combine these molecular aspects with a plausible scenario concerning the evolutionary origin of this phagocyte receptor in the light of host pathogen adaptation.

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570 Biowissenschaften, Biologie

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ITAM, Signal transduction, Phagocytosis, Host pathogen coevolution

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ISO 690PILS, Stefan, Dave T. GERRARD, Axel MEYER, Christof R. HAUCK, 2008. CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogens. In: International Journal of Medical Microbiology. 2008, 298(7-8), pp. 553-560. ISSN 1438-4221. eISSN 1618-0607. Available under: doi: 10.1016/j.ijmm.2008.04.005
BibTex
@article{Pils2008CEACA-8322,
  year={2008},
  doi={10.1016/j.ijmm.2008.04.005},
  title={CEACAM3: An innate immune receptor directed against human-restricted bacterial pathogens},
  number={7-8},
  volume={298},
  issn={1438-4221},
  journal={International Journal of Medical Microbiology},
  pages={553--560},
  author={Pils, Stefan and Gerrard, Dave T. and Meyer, Axel and Hauck, Christof R.}
}
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