@article{Lang2001Topog-8760,
  year={2001},
  doi={10.1006/mcne.2000.0936},
  title={Topographic Restriction of TAG-1 Expression in the Developing Retinotectal Pathway and Target Dependent Reexpression during Axon Regeneration},
  number={2},
  volume={17},
  issn={1044-7431},
  journal={Molecular and Cellular Neuroscience},
  pages={398--414},
  author={Lang, Dirk M. and Warren, James T. and Klisa, Christiane and Stürmer, Claudia}
}

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    <dc:creator>Klisa, Christiane</dc:creator>
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    <dcterms:bibliographicCitation>First publ. in: Molecular and Cellular Neuroscience 17 (2001), 2, pp. 398-414</dcterms:bibliographicCitation>
    <dc:contributor>Stürmer, Claudia</dc:contributor>
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    <dc:contributor>Warren, James T.</dc:contributor>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:46:15Z</dc:date>
    <dc:contributor>Lang, Dirk M.</dc:contributor>
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    <dcterms:abstract xml:lang="eng">TAG-1, a glycosylphosphatidyl inositol (GPI)-anchored protein of the immunoglobulin (Ig) superfamily, exhibits an unusual spatiotemporal expression pattern in the fish visual pathway. Using in situ hybridization and new antibodies (Abs) against fish TAG-1 we show that TAG-1 mRNA and anti-TAG-1 staining is restricted to nasal retinal ganglion cells (RGCs) in 24- to 72-h-old zebrafish embryos and in the adult, continuously growing goldfish retina. Anti-TAG-1 Abs selectively label nasal RGC axons in the nerve, optic tract, and tectum. Axotomized RGCs reexpress TAG-1, which occurs as late as 12 days after optic nerve lesion, when regenerating RGC axons arrive in the tectum, suggesting TAG-1 reexpression is target contactdependent. Accordingly, TAG-1 reexpression ceases upon interruption of the regenerating projection by a second lesion. The topographic restriction of TAG-1 expression and its target dependency during regeneration suggests that TAG-1 might play a role in the retinotopic organization and restoration of the retinotectal pathway.</dcterms:abstract>
    <dcterms:title>Topographic Restriction of TAG-1 Expression in the Developing Retinotectal Pathway and Target Dependent Reexpression during Axon Regeneration</dcterms:title>
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