Recognition of Remote Mismatches by DNA Polymerases

Strerath, Michael; Gaster, Jens; Marx, Andreas

Recognition of Remote Mismatches by DNA Polymerases

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Date

2004

Authors

Strerath, Michael

Gaster, Jens

Marx, Andreas

DOI (citable link)

10.1002/cbic.200400107

Collections

Chemie

Publication type

Journal article

Publication status

Published

Published in

ChemBioChem ; 5 (2004), 11. - pp. 1585-1588. - ISSN 1439-4227. - eISSN 1439-7633

Abstract

We show that DNA polymerases inspect mismatches within the primer–template complex up to four positions distal to the catalytic center, as shown. Insights into enzyme transitions were drawn by chemical probes and extended to direct analysis of single nucleotide variations through allele-specific PCR.

Subject (DDC)

540 Chemistry

Cite This

ISO 690

STRERATH, Michael, Jens GASTER, Andreas MARX, 2004. Recognition of Remote Mismatches by DNA Polymerases. In: ChemBioChem. 5(11), pp. 1585-1588. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.200400107

BibTex

@article{Strerath2004-11-05Recog-33856,
  year={2004},
  doi={10.1002/cbic.200400107},
  title={Recognition of Remote Mismatches by DNA Polymerases},
  number={11},
  volume={5},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={1585--1588},
  author={Strerath, Michael and Gaster, Jens and Marx, Andreas}
}

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