Optogenetic approaches to investigate spatiotemporal signaling during development
Optogenetic approaches to investigate spatiotemporal signaling during development
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Date
2020
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Rogers, Katherine W.
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Gradients and tisse patterning / Small, Stephen; Briscoe, James (ed.). - Cambridge, MA : Elsevier, Academic Press, 2020. - (Current topics in developmental biology ; 137). - pp. 37-77. - ISBN 978-0-12-812790-2
Abstract
Embryogenesis is coordinated by signaling pathways that pattern the developing organism. Many aspects of this process are not fully understood, including how signaling molecules spread through embryonic tissues, how signaling amplitude and dynamics are decoded, and how multiple signaling pathways cooperate to pattern the body plan. Optogenetic approaches can be used to address these questions by providing precise experimental control over a variety of biological processes. Here, we review how these strategies have provided new insights into developmental signaling and discuss how they could contribute to future investigations.
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570 Biosciences, Biology
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Optogenetics, Signaling, Embryogenesis, Pattern formation, Spatiotemporal dynamics
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ROGERS, Katherine W., Patrick MÜLLER, 2020. Optogenetic approaches to investigate spatiotemporal signaling during development. In: SMALL, Stephen, ed., James BRISCOE, ed.. Gradients and tisse patterning. Cambridge, MA:Elsevier, Academic Press, pp. 37-77. ISBN 978-0-12-812790-2. Available under: doi: 10.1016/bs.ctdb.2019.11.009BibTex
@incollection{Rogers2020Optog-56435, year={2020}, doi={10.1016/bs.ctdb.2019.11.009}, title={Optogenetic approaches to investigate spatiotemporal signaling during development}, number={137}, isbn={978-0-12-812790-2}, publisher={Elsevier, Academic Press}, address={Cambridge, MA}, series={Current topics in developmental biology}, booktitle={Gradients and tisse patterning}, pages={37--77}, editor={Small, Stephen and Briscoe, James}, author={Rogers, Katherine W. and Müller, Patrick} }
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