DNA polymerase-catalyzed incorporation of nucleotides modified with a G-quadruplex-derived DNAzyme

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Chemical Communications. 2015, 51(34), pp. 7379-7381. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/C5CC01387A
Zusammenfassung

We show that nucleotides which are modified with a G-quadruplex-derived DNAzyme are substrates for DNA polymerases. Based on this finding we developed a naked-eye detection system that allows the detection of single nucleotide variations in DNA.

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ISO 690VERGA, Daniela, Moritz WELTER, Anna-Lena STECK, Andreas MARX, 2015. DNA polymerase-catalyzed incorporation of nucleotides modified with a G-quadruplex-derived DNAzyme. In: Chemical Communications. 2015, 51(34), pp. 7379-7381. ISSN 0009-241X. eISSN 1364-548X. Available under: doi: 10.1039/C5CC01387A
BibTex
@article{Verga2015polym-30983,
  year={2015},
  doi={10.1039/C5CC01387A},
  title={DNA polymerase-catalyzed incorporation of nucleotides modified with a G-quadruplex-derived DNAzyme},
  number={34},
  volume={51},
  issn={0009-241X},
  journal={Chemical Communications},
  pages={7379--7381},
  author={Verga, Daniela and Welter, Moritz and Steck, Anna-Lena and Marx, Andreas}
}
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