Construction of a variability map for eukaryotic large subunit ribosomal RNA

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Construction_of_a_variability_map_1999.pdf
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1999
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Ben Ali, Abdelghani
Wuyts, Jan
Wachter, Rupert de
Peer, Yves van de
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Nucleic Acids Research. 1999, 27(14), pp. 2825-2831. eISSN 1362-4962. Available under: doi: 10.1093/nar/27.14.2825
Zusammenfassung

In this paper, we present a variability map of the eukaryotic large subunit ribosomal RNA, showing the distribution of variable and conserved sites in this molecule. The variability of each site in this map is indicated by means of a colored dot. Construction of the variability map was based on the substitution rate calibration (SRC) method, in which the substitution rate of each nucleotide site is computed by looking at the frequency with which sequence pairs differ at that site as a function of their evolutionary distance. Variability maps constructed by this method provide a much more accurate and objective description of site-to-site variability than visual inspection of sequence alignments.

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570 Biowissenschaften, Biologie
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ISO 690BEN ALI, Abdelghani, Jan WUYTS, Rupert de WACHTER, Axel MEYER, Yves van de PEER, 1999. Construction of a variability map for eukaryotic large subunit ribosomal RNA. In: Nucleic Acids Research. 1999, 27(14), pp. 2825-2831. eISSN 1362-4962. Available under: doi: 10.1093/nar/27.14.2825
BibTex
@article{BenAli1999Const-7082,
  year={1999},
  doi={10.1093/nar/27.14.2825},
  title={Construction of a variability map for eukaryotic large subunit ribosomal RNA},
  number={14},
  volume={27},
  journal={Nucleic Acids Research},
  pages={2825--2831},
  author={Ben Ali, Abdelghani and Wuyts, Jan and Wachter, Rupert de and Meyer, Axel and Peer, Yves van de}
}
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