Irradiation-induced progenitor cell death in the developing brain is resistant to erythropoietin treatment and caspase inhibition

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2004
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Fukuda, H
Fukuda, A
Zhu, C
Korhonen, Laura
Swanpalmer, John
Hertzman, Sven
Lannering, Birgitta
Lindholm, Dan
Björk-Eriksson, Thomas
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One hemisphere of postnatal day 8 (P8) rats or P10 mice was irradiated with a single dose of 4-12 Gy, and animals were killed from 2 h to 8 weeks after irradiation (IR). In the subventricular zone (SVZ) and the granular cell layer (GCL) of the dentate gyrus, harboring neural and other progenitor cells, nitrosylation and p53 peaked 2-12 h after IR, followed by markers for active caspase-3, apoptosis-inducing factor and TUNEL (6-24 h). Ki67-positive (proliferating) cells had disappeared by 12 h and partly reappeared by 7 days post-IR. The SVZ and GCL areas decreased approximately 50% 7 days after IR. The development of white matter was hampered, resulting in 50-70% less myelin basic protein staining. Pretreatment with erythropoietin did not confer protection against IR. Caspase inhibition by overexpression of XIAP prevented caspase-9 and caspase-3 activation but not cell death, presumably because of increased caspase-independent cell death.

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ISO 690FUKUDA, H, A FUKUDA, C ZHU, Laura KORHONEN, John SWANPALMER, Sven HERTZMAN, Marcel LEIST, Birgitta LANNERING, Dan LINDHOLM, Thomas BJÖRK-ERIKSSON, 2004. Irradiation-induced progenitor cell death in the developing brain is resistant to erythropoietin treatment and caspase inhibition. In: Cell Death and Differentiation. 2004, 11(11), pp. 1166-1178. ISSN 1350-9047. eISSN 1476-5403. Available under: doi: 10.1038/sj.cdd.4401472
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@article{Fukuda2004Irrad-41033,
  year={2004},
  doi={10.1038/sj.cdd.4401472},
  title={Irradiation-induced progenitor cell death in the developing brain is resistant to erythropoietin treatment and caspase inhibition},
  number={11},
  volume={11},
  issn={1350-9047},
  journal={Cell Death and Differentiation},
  pages={1166--1178},
  author={Fukuda, H and Fukuda, A and Zhu, C and Korhonen, Laura and Swanpalmer, John and Hertzman, Sven and Leist, Marcel and Lannering, Birgitta and Lindholm, Dan and Björk-Eriksson, Thomas}
}
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