Neuropsychological Outcome in Subthalamic Nucleus Stimulation Surgeries with Electrodes Passing through the Caudate Nucleus

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2016
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Isler, Cihan
Schaper, Frédéric L. W. V. J.
Temel, Yasin
Duits, Annelien
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Stereotactic and functional neurosurgery. Karger. 2016, 94(6), pp. 413-420. ISSN 0010-5678. eISSN 1423-0372. Available under: doi: 10.1159/000453278
Zusammenfassung

Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson disease (PD) is associated with postoperative cognitive decline. One of the proposed underlying mechanisms is the surgical procedure with the lead trajectory penetrating the caudate nucleus.
Objective: To study whether penetration of the caudate nucleus affects neuropsychological outcome.
Methods: Neuropsychological and imaging data of 30 PD patients who underwent bilateral STN DBS were analysed. Lead trajectories were evaluated leading to a group with (n = 10) and a group without penetration of the caudate nucleus (n = 20). The neuropsychological performance of each group was compared to baseline, both at 3 and 12 months postoperatively.
Results: Only the Trail-Making Test part B (TMT-B) showed an interaction effect within the groups over time at 3 months postoperatively. At 12 months postoperatively, there was only a main effect of time with a decrease in performance in TMT-B for both groups. Also verbal fluency showed a significant decrease over time for both groups at 3 and 12 months postoperatively.
Conclusion: Caudate nucleus penetration affects cognitive flexibility only in the short term after surgery.

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Fachgebiet (DDC)
570 Biowissenschaften, Biologie
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Deep brain stimulation, Caudate nucleus, Cognitive decline, Neuropsychological outcome, Subthalamic nucleus
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ISO 690ISLER, Cihan, Angela ALBI, Frédéric L. W. V. J. SCHAPER, Yasin TEMEL, Annelien DUITS, 2016. Neuropsychological Outcome in Subthalamic Nucleus Stimulation Surgeries with Electrodes Passing through the Caudate Nucleus. In: Stereotactic and functional neurosurgery. Karger. 2016, 94(6), pp. 413-420. ISSN 0010-5678. eISSN 1423-0372. Available under: doi: 10.1159/000453278
BibTex
@article{Isler2016Neuro-50222,
  year={2016},
  doi={10.1159/000453278},
  title={Neuropsychological Outcome in Subthalamic Nucleus Stimulation Surgeries with Electrodes Passing through the Caudate Nucleus},
  number={6},
  volume={94},
  issn={0010-5678},
  journal={Stereotactic and functional neurosurgery},
  pages={413--420},
  author={Isler, Cihan and Albi, Angela and Schaper, Frédéric L. W. V. J. and Temel, Yasin and Duits, Annelien}
}
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    <dcterms:abstract xml:lang="eng">Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson disease (PD) is associated with postoperative cognitive decline. One of the proposed underlying mechanisms is the surgical procedure with the lead trajectory penetrating the caudate nucleus.&lt;br /&gt;Objective: To study whether penetration of the caudate nucleus affects neuropsychological outcome.&lt;br /&gt;Methods: Neuropsychological and imaging data of 30 PD patients who underwent bilateral STN DBS were analysed. Lead trajectories were evaluated leading to a group with (n = 10) and a group without penetration of the caudate nucleus (n = 20). The neuropsychological performance of each group was compared to baseline, both at 3 and 12 months postoperatively.&lt;br /&gt;Results: Only the Trail-Making Test part B (TMT-B) showed an interaction effect within the groups over time at 3 months postoperatively. At 12 months postoperatively, there was only a main effect of time with a decrease in performance in TMT-B for both groups. Also verbal fluency showed a significant decrease over time for both groups at 3 and 12 months postoperatively.&lt;br /&gt;Conclusion: Caudate nucleus penetration affects cognitive flexibility only in the short term after surgery.</dcterms:abstract>
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