Mineralized self-assembled peptides on 3D laser-made scaffolds : a new route toward 'scaffold on scaffold' hard tissue engineering

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2013
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Terzaki, Konstantina
Kalloudi, Erifyli
Mossou, Estelle
Mitchell, Edward P.
Forsyth, V. Trevor
Simon, Paul
Vamvakaki, Maria
Chatzinikolaidou, Maria
Mitraki, Anna
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Biofabrication. 2013, 5(4), 045002. ISSN 1758-5082. eISSN 1758-5090. Available under: doi: 10.1088/1758-5082/5/4/045002
Zusammenfassung

In this study, we propose a new approach to hard tissue regeneration based on the mineralization of 3D scaffolds made using lasers. To this end, we report the rational design of aspartate-containing self-assembling peptides targeted for calcium binding. We further investigate the suitability of these peptides to support cell attachment and proliferation when coupled on a hybrid organic–inorganic structurable material, and evaluate the response of pre-osteoblastic cells on functionalized 3D scaffolds and material surfaces. Our results show that the mineralized peptide, when immobilized on a hybrid photo-structurable material strongly supports cell adhesion, a proliferation increase after three and seven days in culture, and exhibits a statistically significant increase of biomineralization. We propose this strategy as a 'scaffold on scaffold' approach for hard tissue regeneration.

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ISO 690TERZAKI, Konstantina, Erifyli KALLOUDI, Estelle MOSSOU, Edward P. MITCHELL, V. Trevor FORSYTH, Elena V. STURM, Paul SIMON, Maria VAMVAKAKI, Maria CHATZINIKOLAIDOU, Anna MITRAKI, Maria FARSARI, 2013. Mineralized self-assembled peptides on 3D laser-made scaffolds : a new route toward 'scaffold on scaffold' hard tissue engineering. In: Biofabrication. 2013, 5(4), 045002. ISSN 1758-5082. eISSN 1758-5090. Available under: doi: 10.1088/1758-5082/5/4/045002
BibTex
@article{Terzaki2013-12Miner-43503,
  year={2013},
  doi={10.1088/1758-5082/5/4/045002},
  title={Mineralized self-assembled peptides on 3D laser-made scaffolds : a new route toward 'scaffold on scaffold' hard tissue engineering},
  number={4},
  volume={5},
  issn={1758-5082},
  journal={Biofabrication},
  author={Terzaki, Konstantina and Kalloudi, Erifyli and Mossou, Estelle and Mitchell, Edward P. and Forsyth, V. Trevor and Sturm, Elena V. and Simon, Paul and Vamvakaki, Maria and Chatzinikolaidou, Maria and Mitraki, Anna and Farsari, Maria},
  note={Article Number: 045002}
}
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