Quality control data of physiological and immunological biomarkers measured in serum and plasma

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2015
Autor:innen
Jansen, Eugène
Beekhof, Piet
Cremers, Johannes
Weinberger, Birgit
Fiegl, Simone
Toussaint, Olivier
Bernhard, Jürgen
Gonos, Efstathios
Capri, Miriam
Franceschi, Claudio
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MARK-AGE: European study to establish biomarkers of human ageing
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Mechanisms of Ageing and Development. 2015, 151, pp. 54-59. ISSN 0047-6374. eISSN 1872-6216. Available under: doi: 10.1016/j.mad.2015.06.004
Zusammenfassung

In two work packages of the MARK-AGE project, 37 immunological and physiological biomarkers were measured in 3637 serum, plasma or blood samples in five batches during a period of 4 years.
The quality of the serum and plasma samples was very good as judged by the low number of biomarker measurements (only 0.2%) that were rejected because of a high hemolysis, icteria or lipemia of the samples.
Using quality control samples, day-to-day and batch variations were determined. The mean inter-assay variation of the five batches were all below 8%, with an average inter-assay coefficient of variation of all biomarkers of 4.0%. Also the precision of the measurements was very good, because all measurements were between 90% and 115% of the defined target values.
A possible mix-up of samples was determined by comparison of the extreme testosterone levels of men and women. It was concluded that 3% of the sample identification could be mixed-up.
Considering the complex procedure from collection to analysis, including preparation, handling, shipment and storage, of the samples in the MARK-AGE project, both the quality of the samples and the quality of the measurements are very good.

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570 Biowissenschaften, Biologie
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ISO 690JANSEN, Eugène, Piet BEEKHOF, Johannes CREMERS, Birgit WEINBERGER, Simone FIEGL, Olivier TOUSSAINT, Jürgen BERNHARD, Efstathios GONOS, Miriam CAPRI, Claudio FRANCESCHI, Ewa SIKORA, Maria MORENO-VILLANUEVA, Nicolle BREUSING, Tilman GRUNE, Alexander BÜRKLE, Martijn E. T. DOLLÉ, 2015. Quality control data of physiological and immunological biomarkers measured in serum and plasma. In: Mechanisms of Ageing and Development. 2015, 151, pp. 54-59. ISSN 0047-6374. eISSN 1872-6216. Available under: doi: 10.1016/j.mad.2015.06.004
BibTex
@article{Jansen2015Quali-32110,
  year={2015},
  doi={10.1016/j.mad.2015.06.004},
  title={Quality control data of physiological and immunological biomarkers measured in serum and plasma},
  volume={151},
  issn={0047-6374},
  journal={Mechanisms of Ageing and Development},
  pages={54--59},
  author={Jansen, Eugène and Beekhof, Piet and Cremers, Johannes and Weinberger, Birgit and Fiegl, Simone and Toussaint, Olivier and Bernhard, Jürgen and Gonos, Efstathios and Capri, Miriam and Franceschi, Claudio and Sikora, Ewa and Moreno-Villanueva, Maria and Breusing, Nicolle and Grune, Tilman and Bürkle, Alexander and Dollé, Martijn E. T.}
}
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