No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat

Lade...
Vorschaubild
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
2015
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Biology Letters. 2015, 11(9), 20150576. ISSN 1744-9561. eISSN 1744-957X. Available under: doi: 10.1098/rsbl.2015.0576
Zusammenfassung

Bat immune systems may allow them to respond to zoonotic agents more efficiently than other mammals. As the first line of defence, the taxonomically conserved acute phase immune reaction of leucocytosis and fever is crucial for coping with infections, but it is unknown if this response is a key constituent to bat immunological success. We investigated the acute phase reaction to a standard lipopolysaccharide (LPS) challenge in Pallas's mastiff bats (Molossus molossus). Challenged bats lost mass, but in contrast to other mammals showed no leucocytosis or fever. There also was no influence on body temperature reduction during torpor. When compared to recent genome-wide assays for constituent immune genes, this lack of a conserved fever response to LPS contributes to a clearer understanding of the innate immune system in bat species and of the coevolution of bats with a wide diversity of pathogens.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
lipopolysaccharide, white blood, cell count, Molossus, immune response, toll-like receptor 4, mass loss
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690STOCKMAIER, Sebastian, Dina K. N. DECHMANN, Rachel A. PAGE, Michael Teague O'MARA, 2015. No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat. In: Biology Letters. 2015, 11(9), 20150576. ISSN 1744-9561. eISSN 1744-957X. Available under: doi: 10.1098/rsbl.2015.0576
BibTex
@article{Stockmaier2015fever-32939,
  year={2015},
  doi={10.1098/rsbl.2015.0576},
  title={No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat},
  number={9},
  volume={11},
  issn={1744-9561},
  journal={Biology Letters},
  author={Stockmaier, Sebastian and Dechmann, Dina K. N. and Page, Rachel A. and O'Mara, Michael Teague},
  note={Article Number: 20150576}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/32939">
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:issued>2015</dcterms:issued>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-02-11T08:56:18Z</dc:date>
    <dc:creator>Page, Rachel A.</dc:creator>
    <dc:contributor>Stockmaier, Sebastian</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>O'Mara, Michael Teague</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-02-11T08:56:18Z</dcterms:available>
    <dc:language>eng</dc:language>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/32939"/>
    <dc:creator>Stockmaier, Sebastian</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <dc:creator>O'Mara, Michael Teague</dc:creator>
    <dc:contributor>Dechmann, Dina K. N.</dc:contributor>
    <dcterms:title>No fever and leucocytosis in response to a lipopolysaccharide challenge in an insectivorous bat</dcterms:title>
    <dc:contributor>Page, Rachel A.</dc:contributor>
    <dcterms:abstract xml:lang="eng">Bat immune systems may allow them to respond to zoonotic agents more efficiently than other mammals. As the first line of defence, the taxonomically conserved acute phase immune reaction of leucocytosis and fever is crucial for coping with infections, but it is unknown if this response is a key constituent to bat immunological success. We investigated the acute phase reaction to a standard lipopolysaccharide (LPS) challenge in Pallas's mastiff bats (Molossus molossus). Challenged bats lost mass, but in contrast to other mammals showed no leucocytosis or fever. There also was no influence on body temperature reduction during torpor. When compared to recent genome-wide assays for constituent immune genes, this lack of a conserved fever response to LPS contributes to a clearer understanding of the innate immune system in bat species and of the coevolution of bats with a wide diversity of pathogens.</dcterms:abstract>
    <dc:creator>Dechmann, Dina K. N.</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen