Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease

Schoemaker, Dorothee; Poirier, Judes; Escobar, Sophia; Gauthier, Serge; Pruessner, Jens C.

Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease

Dateien

Pruessner_0-400556.pdfGröße: 707.09 KBDownloads: 210

Datum

2016

Autor:innen

Schoemaker, Dorothee

Poirier, Judes

Escobar, Sophia

Gauthier, Serge

Pruessner, Jens C.

Open Access-Veröffentlichung

Open Access Gold

Sammlungen

Psychologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2016, 2, pp. 132-139. eISSN 2352-8729. Available under: doi: 10.1016/j.dadm.2015.11.007

Zusammenfassung

Introduction

Familiarity has been associated with integrity of the rhinal cortex. Thus, impairment in familiarity is expected in very early stages of Alzheimer's disease (AD). The apolipoprotein E (APOE) ε4 allele is a major risk factor for AD. Here, we investigated the effect of the APOE ε4 status on familiarity in cognitively normal aging individuals.

Methods

Eighty-one individuals aged between 55 and 80 years, 21 carriers and 60 noncarriers, were used in these analyses. A cognitive evaluation was performed on all participants to document the absence of objective cognitive deficits. The effect of APOE ε4 status on familiarity was tested using independent sample t test and an analysis of covariance controlling for age, gender, and education.

Results

The groups did not differ in term of age, education, and male/female ratio. APOE ε4 carriers showed a significant reduction in familiarity. No other cognitive deficit was observed in the group of ε4 carriers, relative to noncarriers.

Discussion

APOE ε4 is associated with a reduction in familiarity in the absence of other cognitive deficits. These results suggest that performance in familiarity could represent an early cognitive marker for individuals at risk of AD.

Fachgebiet (DDC)

150 Psychologie

Zitieren

ISO 690

SCHOEMAKER, Dorothee, Judes POIRIER, Sophia ESCOBAR, Serge GAUTHIER, Jens C. PRUESSNER, 2016. Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease. In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2016, 2, pp. 132-139. eISSN 2352-8729. Available under: doi: 10.1016/j.dadm.2015.11.007

BibTex

@article{Schoemaker2016Selec-38161,
  year={2016},
  doi={10.1016/j.dadm.2015.11.007},
  title={Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease},
  volume={2},
  journal={Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring},
  pages={132--139},
  author={Schoemaker, Dorothee and Poirier, Judes and Escobar, Sophia and Gauthier, Serge and Pruessner, Jens C.}
}

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