Publikation:

Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease

Vorschaubild

Dateien

Pruessner_0-400556.pdf
Pruessner_0-400556.pdfGröße: 707.09 KBDownloads: 219

Datum

2016

Autor:innen

Schoemaker, Dorothee
Poirier, Judes
Escobar, Sophia
Gauthier, Serge

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-0-400556
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.dadm.2015.11.007
ArXiv-ID

Internationale Patentnummer

Link zur Lizenz

CC BY-NC-ND 4.0

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Gold

Sammlungen

Psychologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2016, 2, pp. 132-139. eISSN 2352-8729. Available under: doi: 10.1016/j.dadm.2015.11.007

Zusammenfassung

Introduction

Familiarity has been associated with integrity of the rhinal cortex. Thus, impairment in familiarity is expected in very early stages of Alzheimer's disease (AD). The apolipoprotein E (APOE) ε4 allele is a major risk factor for AD. Here, we investigated the effect of the APOE ε4 status on familiarity in cognitively normal aging individuals.

Methods

Eighty-one individuals aged between 55 and 80 years, 21 carriers and 60 noncarriers, were used in these analyses. A cognitive evaluation was performed on all participants to document the absence of objective cognitive deficits. The effect of APOE ε4 status on familiarity was tested using independent sample t test and an analysis of covariance controlling for age, gender, and education.

Results

The groups did not differ in term of age, education, and male/female ratio. APOE ε4 carriers showed a significant reduction in familiarity. No other cognitive deficit was observed in the group of ε4 carriers, relative to noncarriers.

Discussion

APOE ε4 is associated with a reduction in familiarity in the absence of other cognitive deficits. These results suggest that performance in familiarity could represent an early cognitive marker for individuals at risk of AD.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
150 Psychologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690SCHOEMAKER, Dorothee, Judes POIRIER, Sophia ESCOBAR, Serge GAUTHIER, Jens C. PRUESSNER, 2016. Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease. In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2016, 2, pp. 132-139. eISSN 2352-8729. Available under: doi: 10.1016/j.dadm.2015.11.007
BibTex
@article{Schoemaker2016Selec-38161,
  year={2016},
  doi={10.1016/j.dadm.2015.11.007},
  title={Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease},
  volume={2},
  journal={Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring},
  pages={132--139},
  author={Schoemaker, Dorothee and Poirier, Judes and Escobar, Sophia and Gauthier, Serge and Pruessner, Jens C.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/38161">
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38161"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Escobar, Sophia</dc:contributor>
    <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 International</dc:rights>
    <dcterms:issued>2016</dcterms:issued>
    <dc:creator>Pruessner, Jens C.</dc:creator>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/38161/1/Pruessner_0-400556.pdf"/>
    <dcterms:title>Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease</dcterms:title>
    <dc:contributor>Pruessner, Jens C.</dc:contributor>
    <dc:contributor>Gauthier, Serge</dc:contributor>
    <dc:contributor>Poirier, Judes</dc:contributor>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/4.0/"/>
    <dc:language>eng</dc:language>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-03-28T08:55:43Z</dcterms:available>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:creator>Schoemaker, Dorothee</dc:creator>
    <dc:creator>Gauthier, Serge</dc:creator>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/38161/1/Pruessner_0-400556.pdf"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-03-28T08:55:43Z</dc:date>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dcterms:abstract xml:lang="eng">Introduction&lt;br /&gt;&lt;br /&gt;Familiarity has been associated with integrity of the rhinal cortex. Thus, impairment in familiarity is expected in very early stages of Alzheimer's disease (AD). The apolipoprotein E (APOE) ε4 allele is a major risk factor for AD. Here, we investigated the effect of the APOE ε4 status on familiarity in cognitively normal aging individuals.&lt;br /&gt;&lt;br /&gt;Methods&lt;br /&gt;&lt;br /&gt;Eighty-one individuals aged between 55 and 80 years, 21 carriers and 60 noncarriers, were used in these analyses. A cognitive evaluation was performed on all participants to document the absence of objective cognitive deficits. The effect of APOE ε4 status on familiarity was tested using independent sample t test and an analysis of covariance controlling for age, gender, and education.&lt;br /&gt;&lt;br /&gt;Results&lt;br /&gt;&lt;br /&gt;The groups did not differ in term of age, education, and male/female ratio. APOE ε4 carriers showed a significant reduction in familiarity. No other cognitive deficit was observed in the group of ε4 carriers, relative to noncarriers.&lt;br /&gt;&lt;br /&gt;Discussion&lt;br /&gt;&lt;br /&gt;APOE ε4 is associated with a reduction in familiarity in the absence of other cognitive deficits. These results suggest that performance in familiarity could represent an early cognitive marker for individuals at risk of AD.</dcterms:abstract>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Schoemaker, Dorothee</dc:contributor>
    <dc:creator>Escobar, Sophia</dc:creator>
    <dc:creator>Poirier, Judes</dc:creator>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Diese Publikation teilen