Cell types and coincident synapses in the ellipsoid body of Drosophila

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2014
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Martín-Peña, Alfonso
Acebes, Angel
Rodríguez, José-Rodrigo
Chevalier, Valerie
Casas-Tinto, Sergio
Strauss, Roland
Ferrús, Alberto
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Cellular ultrastructures for signal integration are unknown in any nervous system. The ellipsoid body (EB) of the Drosophila brain is thought to control locomotion upon integration of various modalities of sensory signals with the animal internal status. However, the expected excitatory and inhibitory input convergence that virtually all brain centres exhibit is not yet described in the EB. Based on the EB expression domains of genetic constructs from the choline acetyl transferase (Cha), glutamic acid decarboxylase (GAD) and tyrosine hydroxylase (TH) genes, we identified a new set of neurons with the characteristic ring-shaped morphology (R neurons) which are presumably cholinergic, in addition to the existing GABA-expressing neurons. The R1 morphological subtype is represented in the Cha- and TH-expressing classes. In addition, using transmission electron microscopy, we identified a novel type of synapse in the EB, which exhibits the precise array of two independent active zones over the same postsynaptic dendritic domain, that we named 'agora'. This array is compatible with a coincidence detector role, and represents ~8% of all EB synapses in Drosophila. Presumably excitatory R neurons contribute to coincident synapses. Functional silencing of EB neurons by driving genetically tetanus toxin expression either reduces walking speed or alters movement orientation depending on the targeted R neuron subset, thus revealing functional specialisations in the EB for locomotion control.

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570 Biowissenschaften, Biologie
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central complex, coincidence detectors, development, locomotion control
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ISO 690MARTÍN-PEÑA, Alfonso, Angel ACEBES, José-Rodrigo RODRÍGUEZ, Valerie CHEVALIER, Sergio CASAS-TINTO, Tilman TRIPHAN, Roland STRAUSS, Alberto FERRÚS, 2014. Cell types and coincident synapses in the ellipsoid body of Drosophila. In: European Journal of Neuroscience (EJN). Wiley. 2014, 39(10), pp. 1586-1601. ISSN 0953-816X. eISSN 1460-9568. Available under: doi: 10.1111/ejn.12537
BibTex
@article{MartinPena2014-05types-52719,
  year={2014},
  doi={10.1111/ejn.12537},
  title={Cell types and coincident synapses in the ellipsoid body of Drosophila},
  number={10},
  volume={39},
  issn={0953-816X},
  journal={European Journal of Neuroscience (EJN)},
  pages={1586--1601},
  author={Martín-Peña, Alfonso and Acebes, Angel and Rodríguez, José-Rodrigo and Chevalier, Valerie and Casas-Tinto, Sergio and Triphan, Tilman and Strauss, Roland and Ferrús, Alberto}
}
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