Genetic Control of Collective Behavior in Zebrafish

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Tang_2-kh9u0n268r794.pdf(13.53 MB)
Date
2020
Authors
Tang, Wenlong
Zhang, Guoqiang
Fang, Jian
Serluca, Fabrizio
Li, Jingyao
Xiong, Xiaorui
Fishman, Mark C.
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urn:nbn:de:bsz:352-2-kh9u0n268r794
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10.1016/j.isci.2020.100942
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CC BY-NC-ND 4.0

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Open Access publication
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Biologie
Exzellenzcluster "Centre for the Advanced Study of Collective Behaviour"
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iScience ; 23 (2020), 3. - 100942. - Cell Press. - ISSN 2589-0042. - eISSN 2589-0042
Abstract
Many animals, including humans, have evolved to live and move in groups. In humans, disrupted social interactions are a fundamental feature of many psychiatric disorders. However, we know little about how genes regulate social behavior. Zebrafish may serve as a powerful model to explore this question. By comparing the behavior of wild-type fish with 90 mutant lines, we show that mutations of genes associated with human psychiatric disorders can alter the collective behavior of adult zebrafish. We identify three categories of behavioral variation across mutants: “scattered,” in which fish show reduced cohesion; “coordinated,” in which fish swim more in aligned schools; and “huddled,” in which fish form dense but disordered groups. Changes in individual interaction rules can explain these differences. This work demonstrates how emergent patterns in animal groups can be altered by genetic changes in individuals and establishes a framework for understanding the fundamentals of social information processing.
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570 Biosciences, Biology
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Biological Sciences; Genetics; Behavior Genetics; Behavioral Neuroscience
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ISO 690TANG, Wenlong, Jacob D. DAVIDSON, Guoqiang ZHANG, Katherine E. CONEN, Jian FANG, Fabrizio SERLUCA, Jingyao LI, Xiaorui XIONG, Iain D. COUZIN, Mark C. FISHMAN, 2020. Genetic Control of Collective Behavior in Zebrafish. In: iScience. Cell Press. 23(3), 100942. ISSN 2589-0042. eISSN 2589-0042. Available under: doi: 10.1016/j.isci.2020.100942
BibTex
@article{Tang2020-03-27Genet-50348,
  year={2020},
  doi={10.1016/j.isci.2020.100942},
  title={Genetic Control of Collective Behavior in Zebrafish},
  number={3},
  volume={23},
  issn={2589-0042},
  journal={iScience},
  author={Tang, Wenlong and Davidson, Jacob D. and Zhang, Guoqiang and Conen, Katherine E. and Fang, Jian and Serluca, Fabrizio and Li, Jingyao and Xiong, Xiaorui and Couzin, Iain D. and Fishman, Mark C.},
  note={Article Number: 100942}
}
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