Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice

Lade...
Vorschaubild
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
2017
Autor:innen
Golden, Sam A.
Aleyasin, Hossein
Flanigan, Meghan
Heshmati, Mitra
Takahashi, Aki
Russo, Scott J.
Shaham, Yavin
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Genes, Brain and Behavior. Wiley. 2017, 16(1), pp. 44-55. ISSN 1601-1848. eISSN 1601-183X. Available under: doi: 10.1111/gbb.12310
Zusammenfassung

We recently developed a conditioned place preference (CPP) procedure, commonly used to study rewarding drug effects, to demonstrate that dominant sexually-experienced CD-1 male mice form CPP to contexts previously associated with defeating subordinate male C57BL/6J mice. Here we further characterized conditioned and unconditioned aggression behavior in CD-1 mice. In Exp. 1 we used CD-1 mice that displayed a variable spectrum of unconditioned aggressive behavior toward younger subordinate C57BL/6J intruder mice. We then trained the CD-1 mice in the CPP procedure where one context was intruder-paired, while a different context was not. We then tested for aggression CPP 1 day after training. In Exp. 2, we tested CD-1 mice for aggression CPP 1 day and 18 days after training. In Exp. 3-4, we trained the CD-1 mice to lever-press for palatable food and tested them for footshock punishment-induced suppression of food-reinforced responding. In Exp. 5, we characterized unconditioned aggression in hybrid CD-1 × C57BL/6J D1-Cre or D2-Cre F1 generation crosses. Persistent aggression CPP was observed in CD-1 mice that either immediately attacked C57BL/6J mice during all screening sessions or mice that gradually developed aggressive behavior during the screening phase. In contrast, CD-1 mice that did not attack the C57BL/6J mice during screening did not develop CPP to contexts previously paired with C57BL/6J mice. The aggressive phenotype did not predict resistance to punishment-induced suppression of food-reinforced responding. CD-1 × D1-Cre or D2-Cre F1 transgenic mice showed strong unconditioned aggression. Our study demonstrates that aggression experience causes persistent CPP and introduces transgenic mice for circuit studies of aggression.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Aggression, CD‐1, conditioned place preference, D1‐Cre, D2‐Cre, food self‐administration, mice, punishment, reward
Konferenz
Rezension
undefined / . - undefined, undefined
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Datensätze
Zitieren
ISO 690GOLDEN, Sam A., Hossein ALEYASIN, Conor HEINS, Meghan FLANIGAN, Mitra HESHMATI, Aki TAKAHASHI, Scott J. RUSSO, Yavin SHAHAM, 2017. Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice. In: Genes, Brain and Behavior. Wiley. 2017, 16(1), pp. 44-55. ISSN 1601-1848. eISSN 1601-183X. Available under: doi: 10.1111/gbb.12310
BibTex
@article{Golden2017-01Persi-51716,
  year={2017},
  doi={10.1111/gbb.12310},
  title={Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice},
  number={1},
  volume={16},
  issn={1601-1848},
  journal={Genes, Brain and Behavior},
  pages={44--55},
  author={Golden, Sam A. and Aleyasin, Hossein and Heins, Conor and Flanigan, Meghan and Heshmati, Mitra and Takahashi, Aki and Russo, Scott J. and Shaham, Yavin}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/51716">
    <dc:creator>Heshmati, Mitra</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-11-09T14:56:17Z</dc:date>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Aleyasin, Hossein</dc:contributor>
    <dcterms:abstract xml:lang="eng">We recently developed a conditioned place preference (CPP) procedure, commonly used to study rewarding drug effects, to demonstrate that dominant sexually-experienced CD-1 male mice form CPP to contexts previously associated with defeating subordinate male C57BL/6J mice. Here we further characterized conditioned and unconditioned aggression behavior in CD-1 mice. In Exp. 1 we used CD-1 mice that displayed a variable spectrum of unconditioned aggressive behavior toward younger subordinate C57BL/6J intruder mice. We then trained the CD-1 mice in the CPP procedure where one context was intruder-paired, while a different context was not. We then tested for aggression CPP 1 day after training. In Exp. 2, we tested CD-1 mice for aggression CPP 1 day and 18 days after training. In Exp. 3-4, we trained the CD-1 mice to lever-press for palatable food and tested them for footshock punishment-induced suppression of food-reinforced responding. In Exp. 5, we characterized unconditioned aggression in hybrid CD-1 × C57BL/6J D1-Cre or D2-Cre F1 generation crosses. Persistent aggression CPP was observed in CD-1 mice that either immediately attacked C57BL/6J mice during all screening sessions or mice that gradually developed aggressive behavior during the screening phase. In contrast, CD-1 mice that did not attack the C57BL/6J mice during screening did not develop CPP to contexts previously paired with C57BL/6J mice. The aggressive phenotype did not predict resistance to punishment-induced suppression of food-reinforced responding. CD-1 × D1-Cre or D2-Cre F1 transgenic mice showed strong unconditioned aggression. Our study demonstrates that aggression experience causes persistent CPP and introduces transgenic mice for circuit studies of aggression.</dcterms:abstract>
    <dc:contributor>Heshmati, Mitra</dc:contributor>
    <dc:creator>Aleyasin, Hossein</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/51716"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-11-09T14:56:17Z</dcterms:available>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Heins, Conor</dc:creator>
    <dc:creator>Takahashi, Aki</dc:creator>
    <dc:rights>terms-of-use</dc:rights>
    <dc:creator>Golden, Sam A.</dc:creator>
    <dc:creator>Russo, Scott J.</dc:creator>
    <dc:contributor>Heins, Conor</dc:contributor>
    <dc:contributor>Takahashi, Aki</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:creator>Flanigan, Meghan</dc:creator>
    <dcterms:title>Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice</dcterms:title>
    <dc:creator>Shaham, Yavin</dc:creator>
    <dc:language>eng</dc:language>
    <dc:contributor>Russo, Scott J.</dc:contributor>
    <dc:contributor>Shaham, Yavin</dc:contributor>
    <dc:contributor>Golden, Sam A.</dc:contributor>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Flanigan, Meghan</dc:contributor>
    <dcterms:issued>2017-01</dcterms:issued>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Begutachtet
Ja
Diese Publikation teilen