@article{Muller2009-11Solub-14256,
  year={2009},
  doi={10.1002/eji.200939554},
  title={Soluble TNF-α but not transmembrane TNF-α sensitizes T cells for enhanced activation-induced cell death},
  number={11},
  volume={39},
  issn={0014-2980},
  journal={European Journal of Immunology},
  pages={3171--3180},
  author={Müller, Stefan and Rihs, Silvia and Dayer Schneider, Johanna M. and Paredes, Bruno E. and Seibold, Ingeborg and Brunner, Thomas and Mueller, Christoph}
}

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    <dc:creator>Dayer Schneider, Johanna M.</dc:creator>
    <dc:contributor>Paredes, Bruno E.</dc:contributor>
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    <dc:contributor>Müller, Stefan</dc:contributor>
    <dcterms:abstract xml:lang="eng">In addition to its proinflammatory effects, TNF-α exhibits immunosuppression. Here, we compared the capacities of transmembrane TNF-α (tmTNF) and soluble TNF-α (sTNF) in regulating expansion of activated T cells by apoptosis. Splenic CD4+ T cells from wtTNF, TNF-α-deficient (TNF−/−) and TNF−/− mice expressing a non-cleavable mutant tmTNF showed comparable proliferation rates upon TCR-mediated stimulation. Activation-induced cell death (AICD), however, was significantly attenuated in tmTNF and TNF−/−, compared with wtTNF CD4+ T cells. Addition of sTNF during initial priming was sufficient to enhance susceptibility to AICD in tmTNF and TNF−/− CD4+ T cells to levels seen in wtTNF CD4+ T cells, whereas addition of sTNF only during restimulation failed to enhance AICD. sTNF-induced, enhanced susceptibility to AICD was dependent on both TNF receptors. The reduced susceptibility of tmTNF CD4+ T cells for AICD was also evident in an in vivo model of adoptively transferred CD4+ T-cell-mediated colonic inflammation. Hence, the presence of sTNF during T-cell priming may represent an important mechanism to sensitize activated T cells for apoptosis, thereby attenuating the extent and duration of T-cell reactivities and subsequent T-cell-mediated, excessive inflammation.</dcterms:abstract>
    <dc:creator>Seibold, Ingeborg</dc:creator>
    <dc:creator>Rihs, Silvia</dc:creator>
    <dc:creator>Brunner, Thomas</dc:creator>
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    <dc:creator>Mueller, Christoph</dc:creator>
    <dcterms:title>Soluble TNF-α but not transmembrane TNF-α sensitizes T cells for enhanced activation-induced cell death</dcterms:title>
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    <dc:creator>Müller, Stefan</dc:creator>
    <dcterms:bibliographicCitation>Publ. in: European Journal of Immunology ; 39 (2009), 11. - pp. 3171-3180</dcterms:bibliographicCitation>
    <dc:contributor>Dayer Schneider, Johanna M.</dc:contributor>
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    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-07-29T10:13:08Z</dc:date>
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    <dc:contributor>Mueller, Christoph</dc:contributor>
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    <dc:contributor>Rihs, Silvia</dc:contributor>
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    <dc:creator>Paredes, Bruno E.</dc:creator>
    <dc:contributor>Brunner, Thomas</dc:contributor>
    <dcterms:issued>2009-11</dcterms:issued>
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    <dc:contributor>Seibold, Ingeborg</dc:contributor>
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