TNF: a moonlighting protein at the interface between cancer and infection

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2008
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Hundsberger, Harald
Verin, Alexander
Wiesner, Christoph
Pflüger, Maren
Dulebo, Alexander
Schütt, Wolfgang
Lasters, Ignace
Männel, Daniela N.
Lucas, Rudolf
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Frontiers in Bioscience. 2008, 13(14), pp. 5374-5386. ISSN 1093-9946. eISSN 1093-4715. Available under: doi: 10.2741/3087
Zusammenfassung

The remarkable ability of TNF, especially in combination with Interferon-gamma or melphalan, to inhibit the growth of malignant tumor cells is so far unmatched. Unfortunately, its high systemic toxicity and hepatotoxicity prevent its systemic use in cancer patients. An elegant manner to circumvent this problem is the isolated limb and liver perfusion for the treatment of melanoma, soft tissue sarcoma and liver tumors, respectively, although the latter method can lead to a reversible hepatotoxicity. In order to allow also the treatment of other cancers with TNF, new strategies have to be developed that aim at sensitizing tumor cells to TNF and at reducing its systemic and liver toxicity, without losing its antitumor efficiency. Moreover, the lectin-like domain of TNF, which is spatially distinct from the receptor binding sites, could be useful in reducing cancer treatment-related pulmonary edema formation. This review will discuss some recent developments in these areas, which can lead to a renewed interest in TNF for the systemic treatment of cancer.

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570 Biowissenschaften, Biologie
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ISO 690HUNDSBERGER, Harald, Alexander VERIN, Christoph WIESNER, Maren PFLÜGER, Alexander DULEBO, Wolfgang SCHÜTT, Ignace LASTERS, Daniela N. MÄNNEL, Albrecht WENDEL, Rudolf LUCAS, 2008. TNF: a moonlighting protein at the interface between cancer and infection. In: Frontiers in Bioscience. 2008, 13(14), pp. 5374-5386. ISSN 1093-9946. eISSN 1093-4715. Available under: doi: 10.2741/3087
BibTex
@article{Hundsberger2008moonl-1244,
  year={2008},
  doi={10.2741/3087},
  title={TNF: a moonlighting protein at the interface between cancer and infection},
  number={14},
  volume={13},
  issn={1093-9946},
  journal={Frontiers in Bioscience},
  pages={5374--5386},
  author={Hundsberger, Harald and Verin, Alexander and Wiesner, Christoph and Pflüger, Maren and Dulebo, Alexander and Schütt, Wolfgang and Lasters, Ignace and Männel, Daniela N. and Wendel, Albrecht and Lucas, Rudolf}
}
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