Publikation:

Apoptosis in the Absence of Poly- (ADP-ribose) Polymerase

Vorschaubild

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

1997

Autor:innen

Single, Barbara
Künstle, Gerald
Volbracht, Christiane
Hentze, Hannes

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

URI (zitierfähiger Link)
DOI (zitierfähiger Link)
https://doi.org/10.1006/bbrc.1997.6491
ArXiv-ID

Internationale Patentnummer

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung

Sammlungen

Biologie: Publikationen
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Biochemical and Biophysical Research Communications. Elsevier. 1997, 233(2), pp. 518-522. ISSN 0006-291X. eISSN 1090-2104. Available under: doi: 10.1006/bbrc.1997.6491

Zusammenfassung

Cleavage of poly-(ADP-ribose) polymerase is a process occurring early during the execution phase of apoptosis. Although in many experimental systems PARP cleavage indicates a point of no return, the significance of this proteolytic step for apoptosis remains unclear. Here we compare the susceptibility of cells from wild-type mice and PARP−/− mice to several inducers of apoptosis. Neither the susceptibility of hepatocytes towards CD95 or TNF-mediated apoptosis nor the activation of PARP-cleaving caspases was modified in PARP−/− liver cells. Thymocytes with either genotype exhibited similar sensitivity to treatments with ceramide, dexamethasone, or etoposide. The sensitivity of primary neurons towards apoptosis induced by staurosporine, colchicine, potassium withdrawal, peroxynitrite, or the neurotoxin MPP+ was also unaltered. These data suggest that neither activation nor cleavage of PARP has a causal role in apoptotic cell death of primary, non-transformed cells.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690LEIST, Marcel, Barbara SINGLE, Gerald KÜNSTLE, Christiane VOLBRACHT, Hannes HENTZE, Pierluigi NICOTERA, 1997. Apoptosis in the Absence of Poly- (ADP-ribose) Polymerase. In: Biochemical and Biophysical Research Communications. Elsevier. 1997, 233(2), pp. 518-522. ISSN 0006-291X. eISSN 1090-2104. Available under: doi: 10.1006/bbrc.1997.6491
BibTex
@article{Leist1997-04-17Apopt-51280,
  year={1997},
  doi={10.1006/bbrc.1997.6491},
  title={Apoptosis in the Absence of Poly- (ADP-ribose) Polymerase},
  number={2},
  volume={233},
  issn={0006-291X},
  journal={Biochemical and Biophysical Research Communications},
  pages={518--522},
  author={Leist, Marcel and Single, Barbara and Künstle, Gerald and Volbracht, Christiane and Hentze, Hannes and Nicotera, Pierluigi}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/51280">
    <dc:creator>Nicotera, Pierluigi</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-10-09T08:18:04Z</dcterms:available>
    <dc:contributor>Single, Barbara</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/51280"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Nicotera, Pierluigi</dc:contributor>
    <dcterms:title>Apoptosis in the Absence of Poly- (ADP-ribose) Polymerase</dcterms:title>
    <dc:creator>Single, Barbara</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:creator>Leist, Marcel</dc:creator>
    <dc:contributor>Volbracht, Christiane</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-10-09T08:18:04Z</dc:date>
    <dc:creator>Hentze, Hannes</dc:creator>
    <dcterms:abstract xml:lang="eng">Cleavage of poly-(ADP-ribose) polymerase is a process occurring early during the execution phase of apoptosis. Although in many experimental systems PARP cleavage indicates a point of no return, the significance of this proteolytic step for apoptosis remains unclear. Here we compare the susceptibility of cells from wild-type mice and PARP−/− mice to several inducers of apoptosis. Neither the susceptibility of hepatocytes towards CD95 or TNF-mediated apoptosis nor the activation of PARP-cleaving caspases was modified in PARP−/− liver cells. Thymocytes with either genotype exhibited similar sensitivity to treatments with ceramide, dexamethasone, or etoposide. The sensitivity of primary neurons towards apoptosis induced by staurosporine, colchicine, potassium withdrawal, peroxynitrite, or the neurotoxin MPP&lt;sup&gt;+&lt;/sup&gt; was also unaltered. These data suggest that neither activation nor cleavage of PARP has a causal role in apoptotic cell death of primary, non-transformed cells.</dcterms:abstract>
    <dc:contributor>Leist, Marcel</dc:contributor>
    <dc:creator>Volbracht, Christiane</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Hentze, Hannes</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:issued>1997-04-17</dcterms:issued>
    <dc:contributor>Künstle, Gerald</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:creator>Künstle, Gerald</dc:creator>
    <dc:language>eng</dc:language>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Ja
Diese Publikation teilen