Publikation:

Resolving structure and function of metaorganisms through a holistic framework combining reductionist and integrative approaches

Lade...
Vorschaubild

Dateien

Jaspers_2-l7tyl1u6soq74.pdf
Jaspers_2-l7tyl1u6soq74.pdfGröße: 1.64 MBDownloads: 276

Datum

2019

Autor:innen

Jaspers, Cornelia
Fraune, Sebastian
Arnold, A. Elizabeth
Miller, David J.
Bosch, Thomas C. G.

Herausgeber:innen

Kontakt

ISSN der Zeitschrift

Electronic ISSN

ISBN

Bibliografische Daten

Verlag

Schriftenreihe

Auflagebezeichnung

ArXiv-ID

Internationale Patentnummer

Link zur Lizenz

Angaben zur Forschungsförderung

Projekt

Open Access-Veröffentlichung
Open Access Hybrid
Core Facility der Universität Konstanz

Gesperrt bis

Titel in einer weiteren Sprache

Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published

Erschienen in

Zoology. 2019, 133, pp. 81-87. ISSN 0944-2006. eISSN 1873-2720. Available under: doi: 10.1016/j.zool.2019.02.007

Zusammenfassung

Current research highlights the importance of associated microbes in contributing to the functioning, health, and even adaptation of their animal, plant, and fungal hosts. As such, we are witnessing a shift in research that moves away from focusing on the eukaryotic host sensu stricto to research into the complex conglomerate of the host and its associated microorganisms (i.e., microbial eukaryotes, archaea, bacteria, and viruses), the so-called metaorganism, as the biological entity. While recent research supports and encourages the adoption of such an integrative view, it must be understood that microorganisms are not involved in all host processes and not all associated microorganisms are functionally important. As such, our intention here is to provide a critical review and evaluation of perspectives and limitations relevant to studying organisms in a metaorganism framework and the functional toolbox available to do so. We note that marker gene-guided approaches that primarily characterize microbial diversity are a first step in delineating associated microbes but are not sufficient to establish proof of their functional relevance. More sophisticated tools and experiments are necessary to reveal the specific functions of associated microbes. This can be accomplished through the study of metaorganisms in less complex environments, the targeted manipulation of microbial associates, or work at the mechanistic level with the toolbox available in model systems. We conclude that the metaorganism framework is a powerful new concept to help provide answers to longstanding biological questions such as the evolution and ecology of organismal complexity and the importance of organismal symbioses to ecosystem functioning. The intricacy of the metaorganism requires a holistic framework combining reductionist and integrative approaches to resolve the structure and function of its member species and to disclose the various roles that microorganisms play in the biology of their hosts.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

Reductionism, Integrative approach, Holobiont, Adaptation, Model system, Model organism, Aiptasia, Hydra, Nematostella

Konferenz

Rezension
undefined / . - undefined, undefined

Forschungsvorhaben

Organisationseinheiten

Zeitschriftenheft

Zugehörige Datensätze in KOPS

Zitieren

ISO 690JASPERS, Cornelia, Sebastian FRAUNE, A. Elizabeth ARNOLD, David J. MILLER, Thomas C. G. BOSCH, Christian R. VOOLSTRA, 2019. Resolving structure and function of metaorganisms through a holistic framework combining reductionist and integrative approaches. In: Zoology. 2019, 133, pp. 81-87. ISSN 0944-2006. eISSN 1873-2720. Available under: doi: 10.1016/j.zool.2019.02.007
BibTex
@article{Jaspers2019Resol-46294,
  year={2019},
  doi={10.1016/j.zool.2019.02.007},
  title={Resolving structure and function of metaorganisms through a holistic framework combining reductionist and integrative approaches},
  volume={133},
  issn={0944-2006},
  journal={Zoology},
  pages={81--87},
  author={Jaspers, Cornelia and Fraune, Sebastian and Arnold, A. Elizabeth and Miller, David J. and Bosch, Thomas C. G. and Voolstra, Christian R.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/46294">
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-07-10T11:04:43Z</dcterms:available>
    <dcterms:issued>2019</dcterms:issued>
    <dc:contributor>Bosch, Thomas C. G.</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:language>eng</dc:language>
    <dc:contributor>Jaspers, Cornelia</dc:contributor>
    <dc:creator>Arnold, A. Elizabeth</dc:creator>
    <dc:contributor>Arnold, A. Elizabeth</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Fraune, Sebastian</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/46294/1/Jaspers_2-l7tyl1u6soq74.pdf"/>
    <dc:creator>Fraune, Sebastian</dc:creator>
    <dc:contributor>Miller, David J.</dc:contributor>
    <dc:creator>Voolstra, Christian R.</dc:creator>
    <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 International</dc:rights>
    <dc:contributor>Voolstra, Christian R.</dc:contributor>
    <dc:creator>Miller, David J.</dc:creator>
    <dcterms:abstract xml:lang="eng">Current research highlights the importance of associated microbes in contributing to the functioning, health, and even adaptation of their animal, plant, and fungal hosts. As such, we are witnessing a shift in research that moves away from focusing on the eukaryotic host sensu stricto to research into the complex conglomerate of the host and its associated microorganisms (i.e., microbial eukaryotes, archaea, bacteria, and viruses), the so-called metaorganism, as the biological entity. While recent research supports and encourages the adoption of such an integrative view, it must be understood that microorganisms are not involved in all host processes and not all associated microorganisms are functionally important. As such, our intention here is to provide a critical review and evaluation of perspectives and limitations relevant to studying organisms in a metaorganism framework and the functional toolbox available to do so. We note that marker gene-guided approaches that primarily characterize microbial diversity are a first step in delineating associated microbes but are not sufficient to establish proof of their functional relevance. More sophisticated tools and experiments are necessary to reveal the specific functions of associated microbes. This can be accomplished through the study of metaorganisms in less complex environments, the targeted manipulation of microbial associates, or work at the mechanistic level with the toolbox available in model systems. We conclude that the metaorganism framework is a powerful new concept to help provide answers to longstanding biological questions such as the evolution and ecology of organismal complexity and the importance of organismal symbioses to ecosystem functioning. The intricacy of the metaorganism requires a holistic framework combining reductionist and integrative approaches to resolve the structure and function of its member species and to disclose the various roles that microorganisms play in the biology of their hosts.</dcterms:abstract>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/4.0/"/>
    <dcterms:title>Resolving structure and function of metaorganisms through a holistic framework combining reductionist and integrative approaches</dcterms:title>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/46294"/>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/46294/1/Jaspers_2-l7tyl1u6soq74.pdf"/>
    <dc:creator>Jaspers, Cornelia</dc:creator>
    <dc:creator>Bosch, Thomas C. G.</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-07-10T11:04:43Z</dc:date>
  </rdf:Description>
</rdf:RDF>

Interner Vermerk

xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter

Kontakt
URL der Originalveröffentl.

Prüfdatum der URL

Prüfungsdatum der Dissertation

Finanzierungsart

Kommentar zur Publikation

Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja
Diese Publikation teilen